Benzyl formate

Exposure related observations in humans: other data

Administrative data

Endpoint:

exposure-related observations in humans: other data

Type of information:

experimental study

Adequacy of study:

supporting study

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

other: Purity not known.

Data source

Reference

Reference Type:

publication

Title:

Dermal Irritating Properties of Essential oils and Aromatic Chemicals

Author:

Katz A.E.

Year:

1946

Bibliographic source:

The Spice Mill 69: 46-47

Materials and methods

Endpoint addressed:

skin irritation / corrosion

Test guideline

Qualifier:

no guideline followed

GLP compliance:

no

Test material

Test material information

Constituent 1

Reference substance name:

Benzyl formate

EC Number:

203-214-4

EC Name:

Benzyl formate

Cas Number:

104-57-4

Molecular formula:

C8H8O2

IUPAC Name:

benzyl formate

Method

Ethical approval:

not specified

Details on study design:

The test was conducted on adult human male and female volunteer subjects. The test substance was applied in the pure from to an area approximately 1 cm in diameter on the dermis of the inner portion of the lower arm. Immediately following application, the area was covered with an adhesive bandage which was allowed to remain for a period of 24 hours. The test was read at 24-hour intervals for a 5-day period. Applications which produced visible inflamation, irritation, formation of a popular rash, or any abnormal condition of the area, were considered as positive reactions.

Details on exposure:

TYPE OF EXPOSURE: human patch test
Not specified
Details on study design
The test was conducted on adult human male and female volunteer subjects. The test substance was
applied in the pure from to an area approximately 1 cm in diameter on the dermis of the inner portion of
the lower arm. Immediately following application, the area was covered with an adhesive bandage which
was allowed to remain for a period of 24 hours. The test was read at 24-hour intervals for a 5-day period.
Applications which produced visible inflamation, irritation, formation of a popular rash, or any abnormal
condition of the area, were considered as positive reactions.
Details on exposure
TYPE OF EXPOSURE: human patch test
CONCENTRATION: 100 % (undiluted)
EXPOSURE PERIOD: 24 hours
POSTEXPOSURE PERIOD: The test was read after 24-hour intervals for a 5-day period.
CONCENTRATION: 100 % (undiluted)

EXPOSURE PERIOD: 24 hours

POSTEXPOSURE PERIOD: The test was read after 24-hour intervals for a 5-day period.

Results and discussion

Results:

The test substance was non-irritation in a human patch test.

Applicant's summary and conclusion

Conclusions:

The test substance was non-irritation in a human patch test.

Executive summary:

In this study, the irritating properties of several chemicals, including the test item, were tested in a dermal human patch test. The test was conducted on adult human male and female volunteer subjects. The test substance was applied in the pure from to an area approximately 1 cm in diameter on the dermis of the inner portion of the lower arm. Immediately following application, the area was covered with an adhesive bandage which was allowed to remain for a period of 24 hours. The test was read at 24-hour intervals for a 5-day period. Applications which produced visible inflammation, irritation, formation of a popular rash, or any abnormal condition of the area, were considered as positive reactions. In 24 patch tests with the test item, only one positive reaction was observed. Thus, the test item can be considered as non-irritating to the human skin.