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EC number: 203-214-4
CAS number: 104-57-4
acute oral toxicity study was carried out to assess the potential
toxicity of the test substance after a single oral administration. The
acute toxic class method was followed. Three dose groups of three
females each were utilized as follows: Group 1 (Step 1): 2000 mg/kg bw
of the test substance Groups 2 and 3 (Steps 2 and 3): 300 mg/kg bw of
the test substance Step 1: A dose of 2000 mg/kg bw was administered and
then, there were two dead animals at 2000 mg/kg bw (Step 1). Steps 2-3:
There were two dead animals (Step 1), thus a second dose of 300 mg/kg bw
was administered. Then, there was no mortality (Step 2). A third dose of
300 mg/kg bw was administered (Step 3). All animals were monitored for
clinical signs and body weight changes during the 14-day observation
period after administration. They were subjected to a gross necropsy at
the end of the observation period. There were no deaths of animals at
300 mg/kg bw. No test substance-related effects were observed in
clinical signs, body weight data or necropsy findings in any animal at
300 mg/kg bw. Based on the result of the acute oral toxicity study in
Sprague-Dawley rats, the test substance, was classified as Category 4
according to the GHS classification and the median lethal dose derived
was: LD50 = 1000 mg/kg bw.
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