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EC number: 256-032-2
CAS number: 42978-66-5
As a negative control, male mice were
administered merely the vehicle, olive oil,by the same route, which
gave frequencies of micronucleated
polychromatic erythrocytes within the historical control range.
Both of the positive control chemicals, i.e. cyclophosphamide for
clastogenicity and vincristine for spindle poison effects, led to the
expected increase in the rate of polychromatic erythrocytes containing
small or large micronuclei.
Animals which were administered the vehicle or the positive control
substances cyclophosphamide or vincristine did not show any clinical
signs of toxicity.
The administration of the test substance led to clinical signs, namely
piloerection and squatting posture.
According to the results of the present study, the single
intraperitoneal administration of Tripropylenglykoldiacrylat did not
lead to any increase in the number of polychromatic erythrocytes
containing either small or large micronuclei. The rate of micronuclei
was always close to the range as that of the concurrent negative control
in all dose groups and at all sacrifice intervals and within the range
of the historical control data.
A dose-dependent inhibition of erythropoiesis determined from the ratio
of polychromatic to normochromatic erythrocytes was detected from about
of 87.5 mg/kg body weight onward.
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