Registration Dossier

Toxicological information

Skin sensitisation

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Administrative data

Endpoint:
skin sensitisation
Remarks:
in vivo
Type of information:
experimental study
Adequacy of study:
supporting study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Meets generally accepted scientific standards, well documented and acceptable for assessment

Data source

Reference
Reference Type:
publication
Title:
Contact sensitivity to acrylate compounds in guinea pigs
Author:
Parker D, Turk JL
Year:
1983
Bibliographic source:
Contact Dermatitis 9: 55-60

Materials and methods

GLP compliance:
no
Type of study:
other: Contact skin reactions in guinea pigs immunized by the Polak method

Test material

Reference
Name:
Unnamed
Type:
Constituent
Details on test material:
- Name of test material (as cited in study report): Tripropylene glycol diacrylate
- Analytical purity: no data
no further data

In vivo test system

Test animals

Species:
guinea pig
Strain:
Hartley
Sex:
male/female
Details on test animals and environmental conditions:
TEST ANIMALS
- Source: Royal College of Surgeons or David Hall, Newchurch, Staffordshire, England
- Weight at study initiation: 400-500 g
- Diet (e.g. ad libitum): Labsure RGP diet liberally supplemented with cabbage and hay

Study design: in vivo (non-LLNA)

Induction
Route:
intradermal
Vehicle:
other: ethanol:saline 1:4 or acetone:olive oil 4:1
Challenge
Route:
epicutaneous, open
Vehicle:
other: ethanol:saline 1:4 or acetone:olive oil 4:1
No. of animals per dose:
6 animals were used in total

Results and discussion

Any other information on results incl. tables

The skin test concentrations were 0.4% and 1.1%. The first positive skin test was observed after 28 days. Tripropylene glycol diacrylate was judged to be a weak sensitizer.

Applicant's summary and conclusion

Interpretation of results:
sensitising
Remarks:
Migrated information