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EC number: 256-032-2
CAS number: 42978-66-5
The skin test concentrations were 0.5% and 1%. The first positive skin
test was observed after 28 days. The test substance was judged to be a
Skin test concentrations
No. of animals
of first positive skin test
are expressed as the average intensity of the skin reactions at a
certain skin test concentration, of all the animals .
In this non GLP study, contact skin reactions were investigated using
guinea-pigs that were immunized by the Polak method (1983a). On day 7,
the animals received 4 footpad injections of 0.1 ml of an emulsion
containing 2 mg/ml of the chemical, in ethanol:saline (1:4), in Freund's
complete adjuvant (FCA - Difco mycobacterium butyricum). In addition,
0.1 ml of the emulsion was injected into the nape of the neck . The
guinea pigs received a total of 1 mg of chemical. On day 7, open skin
testing was performed by dropping 0.02 ml of a solution of the chemical
in acetone:olive oil (4:1) onto the shaved flank. The concentration of
the skin test solution varied with the chemical and those used were
dilutions of 5% or the maximum concentration which gave no non-specific
irritation. Skin tests were repeated weekly at different sites on the
flank for up to 12 weeks. The skin test concentrations were 0.4% and
1.1%. The first positive skin test was observed after 28 days. The test
substance was judged to be a weak sensitizer.
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