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EC number: 256-032-2
CAS number: 42978-66-5
The study was performed to assess the acute toxicity following oral
administration in Wistar rats in a study performed similar to OECD 401
guideline (GLP not specified).
Single doses of 5,000 mg/kg body weight of the test material
preparations in aqueous carboxymethyl cellulose (5%) were given to 5
male and 5 female fasted rats by gavage. One day after substance
administration, 1 male and 1 female rat died. The dead animals showed
gross pathology findings at the heart (acute dilatation of the
prechambers, acute congestive hyperanemia), stomach (vascular injection)
and intestine (atonic). In animals surviving the observation period of
14 days gross pathology findings at the stomach were investigated and
included gastroesophageal vestibule thickened, sporadic agglutination of
the gastroesophageal vestibule with the peritoneum. Clinical signs
observed throughout the study were dyspnoe, apathy, staggering, scrubby
fur, salivation and bad general condition. The mean body weights of the
administration groups increased throughout the study period.
Under the conditions of this study, the median lethal dose of the test
item after oral administration was found to be greater than 5,000 mg/kg
body weight in rats.
The present skin irritation study was performed similar to OECD
guideline 404 (GLP not specified, reliability 2) with two Vienna White
rabbits (f/m). The animals were treated for 4 h with the undiluted test
substance under occlusive conditions and the skin reactions were
observed for a period of 8 days. Mild skin
effects were seen after exposure. The value for edema formation was 1
over all animals tested and 1 for individual animals. The value for
erythema formation was 1.5 over all animals tested and 2 in the first
animal and 1 in the second animal. In one animal, erythema formation was
not fully reversible at the end of the observation period on day 8.
The acute inhalation toxicity was investigated in an Inhalation Risk
test with rats (reliability 2). The test was performed in principle as
described in OECD test guideline 403 (GLP not specified). It
demonstrates the toxicity of an atmosphere saturated with vapors of the
volatile components of a test substance at 20 °C. Young adult laboratory
rats, 6 per sex, were exposed sequentially to the vapors generated by
bubbling 200 L/h air through a substance column of about 5 cm above a
fritted glass disc in a glass cylinder for 7 hours. No analytical
determination of the atmosphere concentrations was performed. The
nominal concentration was calculated as 0.000545 mg/l based on the vapor
pressure. Group-wise documentation of clinical signs was performed over
a 14 day study period. All animals survided inhalative exposure and
showed no gross pathology findings. Clinical symptoms soley included
wiping of the snout throughout expsoure.
Based on the study findings no acute inhalation toxicity can be
concluded for animals expsosed to a saturated vapor of the test item.
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