Registration Dossier

Administrative data

Description of key information

Dermal:
Rat: subchronic 3 months: No neurotoxic effects were observed up to the highest dose tested in a dermal repeated dose toxicity study including evaluation of neurotoxicity (Bio/Dynamics Inc. 1992, Val. 2, see section on repeated dose, IUCLID 7.5.3)

Key value for chemical safety assessment

Effect on neurotoxicity: via dermal route

Endpoint conclusion
Endpoint conclusion:
no adverse effect observed

Additional information

No neurotoxic effects were observed up to the highest dose tested in a 3 -months dermal repeated dose toxicity study including evaluation of neurotoxicity (Bio/Dynamics Inc. 1992, Val. 2). The study is discussed in full detail in the repeated dose toxicity section.

Justification for classification or non-classification

No classification for neurotoxicity is warranted as no neurotoxic effects were observed in a respective neurotoxicity study.