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There were no studies available in which the toxicokinetic properties of tripropylene glycol diacrylate (TPGDA) were investigated.

 

Tripropylene glycol diacrylate having a molecular weight of 300.35 g/mol is a liquid, which is well soluble in water (solubility: 4 g/l at 25 °C). It has a low volatility of 0.000044 hPa at 20 °C and a log Po/w of 2 at 25 °C.

 

In an acute oral toxicity study in rats (BASF 2004), no mortality and no other signs of toxicity were observed at a dose of 2000 mg/kg body weight. In a further acute oral toxicity study (BASF 1982), in total 2/10 animals died and dyspnoe, apathy, staggering, scrubby fur, salivation and bad general condition were observed, indicating an oral bioavailability of the test material.

There was no mortality in an acute dermal toxicity study with rats (Bio/dynamics Inc. 1980) at a dose of 2000 mg/kg body weight; however clinical signs such as fecal staining, decreased food consumption or clear nasal discharge were observed, indicating bioavailability also via the dermal route. Further support comes from a 90 -day dermal neurotoxicity study in rats (Bio/dynamics Inc. 1982) with doses of 0, 20, 66.66, 200 mg/kg body weight/day. The highest dose led to a significantly reduced body weight in male rats. Bioavailability of the test material via the dermal route is confirmed, as the substance caused sensitization reactions after dermal application.

No deaths were seen in an inhalation hazard test when rats were exposed to the volatile components of the tested material for 7 hours (BASF 1982). Due to the low vapour pressure of the test substance this result can not be used to exclude absorption after inhalation.

 

Considering the chemical structure of TPGDA, liver metabolism will consist of ester hydrolyses, leading to release of acrylic acid and Tripropyleneglycol. In blood, e.g., after dermal uptake, ester hydrolysis plays only a very minor role. Instead, the acrylic group is rapidly conjugated to glutathion (Miller et al. (1981); McCarthy et al. (1994)). Available studies on genotoxicity in-vivo (mouse micronucleus assay) were negative, i.e. there is no indication of a reactivity of tripropylene glycol diacrylate or its metabolites under the test conditions.

 

Taking into account the log Po/w, the water solubility and the considerations on the metabolism, accumulation of tripropylene glycol diacrylate is considered to be unlikely.

Miller, Ayres, Rampy, McKenna (1981). Metabolism of acrylate ester in rat tissue homogenates. Fundamental and applied toxicology 1:410 -414

McCarthy, Hayes, Schwartz, Witz (1994). The reactivity of selected acrylate ester toward glutathione and deoxyribonucleosides in vitro: Structure-activity relationships. Fundamental and applied toxicology 22, 543 -548