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EC number: 256-032-2
CAS number: 42978-66-5
An eye irritation test in rabbits was performed according to the method
described in OECD guideline 405 (GLP, reliability 1). An amount of 0.1
ml of the test substance was applied to one eye of three White New
Zealand rabbits (stepwise procedure starting with one animal and
supplementing two additional animals). About 24 hours after application
the eye was rinsed with tap water. The ocular reactions were assessed
approximately 1, 24, 48, 72 hours and 7 days after application. Slight
corneal opacity, moderate iritis, moderate or severe conjunctival
redness, slight to marked conjunctival chemosis and slight to severe
discharge were observed during the course of the study. In addition
suppuration, contracted pupil, discharge of blood and injected scleral
vessels in a circumscribed area or circular were noted during the
The ocular reactions were reversible in all animals within 7 days after
application. The average score (24 to 72 hours) for irritation was
calculated to be 1.0 for corneal opacity, 0.4 for iris, 2.3 for
conjunctival redness and 1.7 for chemosis. There was one animal with a
mean score of 2.67 for redness, the other two animals were at 2 and 2.33.
Considering the described ocular reactions as well as the average score
for irritation, the test substance shows a slight eye irritation
potential under the test conditions chosen.
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