Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
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EC number: 215-676-4 | CAS number: 1341-49-7
Health surveillance data
Administrative data
- Endpoint:
- health surveillance data
- Type of information:
- other: review
- Adequacy of study:
- key study
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: Summary of available information summarised in the EU RAR
Data source
Reference
- Reference Type:
- review article or handbook
- Title:
- European Union Risk Assessment Report, hydrogen fluoride.
- Author:
- Various
- Year:
- 2 001
- Bibliographic source:
- European Union Risk Assessment Report, Volume 8, Institute for Health and Consumer Protection, European Chemicals Bureau.
Materials and methods
- Study type:
- biological effect monitoring
- Endpoint addressed:
- repeated dose toxicity: oral
Test guideline
- Qualifier:
- no guideline available
- Principles of method if other than guideline:
- Review of the effects of fluoride in exposed populations
- GLP compliance:
- no
Test material
- Reference substance name:
- fluoride (various forms)
- IUPAC Name:
- fluoride (various forms)
- Details on test material:
- Effects of fluoride in drinking water
Constituent 1
Method
- Type of population:
- general
- Ethical approval:
- not applicable
- Details on study design:
- The EU RAR reviews the findings of a number of studies investigating the effects of fluoride
Results and discussion
Any other information on results incl. tables
Severe skeletal fluorosis was reported in humans after prolonged intake of 15 mg/day (215 µg/kg bw/day in an adult weighing 70 kg) and above. In one case, exposure to drinking water containing 8 mg/l fluoride for 37 years resulted in fluoride-induced bone changes, but not in clinical signs. In a community exposed to 4 mg/l fluoride in the drinking water (estimated to be equivalent to 72 µg/kg bw/day) the relative risk for various bone fractures was 2.2 to 2.7 as compared to an "unexposed" control community which received 1 mg/l. However CEPA stated that exposure in the high fluoride community was probably underestimated, while the calcium concentration in the drinking water of this community was only about 25% of that in the control group.
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
