Registration Dossier
Registration Dossier
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EC number: 215-676-4 | CAS number: 1341-49-7
Toxicity to microorganisms
Administrative data
Link to relevant study record(s)
Description of key information
An activated sludge respiration inhibition test was carried out with ammonium hydrogen difluoride, according to OECD method 209: The EC50was in the range 3126 - 4233 mg/l. (Kanne & Hamburger, 1987).
Key value for chemical safety assessment
- EC50 for microorganisms:
- 3 126 mg/L
Additional information
An activated sludge respiration inhibition test was carried out with ammonium hydrogen difluoride, according to OECD method 209: The EC50was in the range 3126 - 4233 mg/l. (Kanne & Hamburger, 1987).
The substance is water-soluble and, in aqueous environments, will dissociate to form hydrogen, fluoride and ammonium ions. Read-across data are available from other soluble fluoride salts. Ammonia is generated as a product of metabolism by bacteria present in STPs from other sources including nitrogenous waste. STPs will therefore contain ammonia generated by bacteria from other sources at potentially much higher levels. Ammonium is readily converted by bacterial species to nitrate, via the process of nitrification. The primary stage of nitrification, the oxidation of ammonium to nitrite (NO2-) is performed by Nitrosomonas (among other) species. Other bacterial species (including Nitrobacter) are responsible for the subsequent oxidation of nitrite to nitrate (NO3-).
A guideline-compliant Bayer study performed with hydrogen fluoride (HF) reports a 3 -hour NOEC of 510 mg/L for activated sludge. The EU RAR summarises and reviews the other available data on the toxicity of soluble fluoride compounds to aquatic microorganisms; NOEC values of between 7.1 -226 mg/L are reported
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