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EC number: 700-840-4
CAS number: 160583-22-2
A study on repeated toxicity is waived due to high reactivity of 2-phenylethyl cyanoacrylate which makes testing not feasable. On contact with moisture, 2-phenylethyl cyanoacrylate polymerizes immediately.
Stability testing demonstrated that
2-phenylethyl cyanoacrylate is a reactive molecule which polymerizes
immediately on contact with moisture, so polymerization will occur
during administration. Due to this high reactivity the determination of
a NOAEL or LOAEL is not possible as 2-phenylethyl cyanoacrylate is not
bioavailable after administration.
Thus, in accordance with annex XI section 2
of Regulation (EC) No 1907/2006 testing of 2-phenylethyl cyanoacrylate
on repeated dose toxicity is waived.
No sub-acute or chronic toxicity is expected since
bioavailability of 2 -phenylethyl cyanoacrylate is unlikely due to its
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