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EC number: 700-840-4
CAS number: 160583-22-2
Study is technically not feasible as 2-phenylethyl cyanoacrylate polymerizes within seconds on contact with moisture.
Stability testing demonstrated that
2-phenylethyl cyanoacrylate is a reactive molecule which polymerizes
immediately on contact with moisture. Due to the compound’s high
reactivity, a study on acute toxicity is technically not feasible, i.e.
the study will not result in any information on potential adverse
effects exerted by the monomer.
Thus, in accordance with annex XI section 2
of Regulation (EC) No 1907/2006 testing of 2-phenylethyl cyanoacrylate
on acute toxicity is waived.
2-Phenylethyl cyanoacrylate shares its high
reactivity with other cyanoacrylates, and its reaction mechanism of
polymerization is identical to that of e.g. ethyl 2-cyanoacrylate. A
study on acute oral toxicity in rats for ethyl 2-cyanoacrylate resulted
in one dead animal with the polymerized compound found residing as a
solid mass in the rat's stomach, being the most probable cause of death.
This observation underlines that only the polymeric form of ethyl
2-cyanoacrylate instead of the monomers could be assessed with this
study. Based on this, the LD50 for ethyl 2-cyanoacrylate was indicated
to be above 5000 mg/kg bw. Similar study results are expected for 2
-phenylethyl cyanoacrylate, therefore additional testing of this
compound in an acute oral toxicity study appears to be scientifically
2 -Phenylethyl cyanoacrylate will polymerize
quickly in contact with water resulting in negligible bioavailability of
the monomer. Based on the fact that for the similar compound 2-ethyl
cyanoacrylate which shows the same mechanism of polymerisation, an oral
LD50 of > 5000 mg/kg body weight and a dermal LD50 of > 2000 mg/kg has
been found, it is concluded that 2 -phenylethyl cyanoacrylate will also
not demonstrate acute toxicity and is thus not classified.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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