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EC number: 700-840-4
CAS number: 160583-22-2
In general, 2 -cyanoacrylates react rapidly in contact with water to
form polymers (within seconds) in exogenous reactions. It is thus
technically not possible to assess the skin sensitizing potential of the
isolated 2-phenylethyl cyanoacrylate monomer. It can be expected that
during the test procedure the monomer reacts with the humidity of the
air and on the skin to form the polymer. This reaction is much faster
than a penetration through skin, making it practically impossible to
expose cells involved in a sensitization reaction to the monomeric
Thus, in accordance with annex XI section 2 of Regulation (EC) No
1907/2006 testing of 2-phenylethyl cyanoacrylate on skin senistization
Allergic reactions towards cyanoacrylate adhesives are occasionally
described in literature. Case reports often lack a clear description
which substance caused the observed reactions. Some authors argue that
the monomer might be of relevance, others argue that degradation
products including formaldehyde could have caused reactions. As the full
composition of the commercial products have not been described in most
of the case reports, it could not be clarified which chemical substances
were present and contributed to the adverse skin effects.
2 -Phenylethyl cyanoacrylate binds instantaneously to the skin's surface
and polymerizes. The polymerized material is not able to penetrate into
the epidermis. Hence, the substance is not considered to be a skin
sensitizer and needs no classification.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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