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EC number: 700-840-4
CAS number: 160583-22-2
LID-1187A and Histoacryl were examined for
mutagenic activity in four histidine-dependent auxotrophs of Salmonella
typhimurium, strains TA 98, TA 100, TA 1535 and TA 1537, using
pour-plate assays. The procedures used complied with OECD Guideline for
Testing of Chemicals No. 471 (issued 1983) and EPA Toxic Substances
Control Act Test Guideline § 798.5265 (first issued 1985, amended 1987).
Each test, in each strain, was conducted on two separate occasions.
The studies, which were conducted in the
absence and presence of an activating system derived from rat liver (S-9
mix), employed a range of levels of both test materials from 25 to 2500 µg
per plate, selected following a preliminary toxicity test in strain TA
98. All tests included solvent (acetone) controls with and without S-9
No increases in reversion to prototrophy
were obtained with any of the four bacterial strains following exposure
to either LID-1187A or Histoacryl at the levels tested, either in the
presence or absence of S-9 mix. Inhibition of growth, observed as
thinning of the background lawn of non-revertant cells and reduction in
revertant colony numbers, occurred in all strains following exposure to
both test materials at 2500 ug per plate.
Marked increases in the number of revertant
colonies were induced by the known mutagens benzo[a]pyrene,
2-nitrofluorene, 2-aminoanthracene, 9-aminoacridine and sodium azide
when examined under similar conditions.
It was concluded that both LID-1187A and
Histoacryl were devoid of mutagenic activity under the conditions of the
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