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EC number: 700-840-4
CAS number: 160583-22-2
PhECA, Charge 3635-59
Texapon ASV, 5% AS
It was observed that the test substance partially polymerized on the
CAM, leaving a sticky cover that could not be rinsed but removed with
forceps. Removing the substance sheet like this did not result in a
problematic damage of the CAM.
The possible ocular irritancy of 2 -phenylethyl cyanoacrylate was tested
with an HET-CAM through topical application for 300 seconds using the
endpoint assessment method. The test substance was applied undiluted
(300 mg) directly on top of the chorioallantoic membrane.
The mean S-score obtained with the positive control (5 % Texapon ASV)
was 11 and within the historical control data range. It was therefore
concluded that the test conditions were adequate and that the test
system functioned properly. The mean S-score obtained with 2
-phenylethyl cyanoacrylate was 0.
Thus, it is concluded that this test is valid and that 2 -phenylethyl
cyanoacrylate is not irritant in the Hen’s Egg Test – Chorioallantoic
Membrane Test under the experimental conditions described in this report.
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