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EC number: 629-732-4
CAS number: 1224966-13-5
Available information indicates that all AAI substances corrosive to skin, and the same should be expected for Tall oil fatty acids, reaction products with polyethylenepolyamines (Amidoamine/Imidazoline).
substances within the AAI group show the same reactive groups, show
similar composition of amide, imidazoline, and some dimer structures of
both, with the length of original EA amines used for production as
biggest difference. Inherent reactivity and toxicity is not expected to
differ much between these substances.
irritation/corrosion studies performed on AAI substances all indicate
them to be corrosive following 4 hour exposure. There do not seem to be
big differences in response with the variation on EA length used for the
production of the AAI.
similar results can be expected for Tall
oil fatty acids, reaction products with polyethylenepolyamines
table below provides an overview of all available for the group of AAI:
+ DETA in vivo: Corrosive: Cat.1C
+ TEPA in vivo: Corrosive: Cat.1C
C18 unsat + TEPA in vivo: Corrosive: Cat.1C
indication for possible threshold effects for irritation comes from an
available sensitisation study on Fatty acids C16-18, C18 unsat
reaction products with tetraethylenepentamine.
a Guinea pig maximization study for dermal sensitization, a
preliminary irritation study evaluated irritation from epidermal
exposures to the substance for 24 hrs under occlusion. The highest
non-irritating concentration for epidermal exposures was established
at 1% in 0.9% NaCl. Epidermal concentrations of 5% resulted to
moderate and confluent erythema.
are no eye irritation studies available on an AAI substance. Corrosion
to the eye is expected based on dermal corrosion.
are no data from inhalation studies. However, exposure by inhalation
is not likely considering the high boiling point (> 300 °C) and very
low vapour pressure (0.00017 mPa at 25°C for DETA based AAI).
Furthermore, as the substance is classified as corrosive, no acute
toxicity testing should normally be conducted.
Tall oil fatty acids, reaction products with
polyethylenepolyamines (Amidoamine/Imidazoline) is expected to be
corrosive following 4 hours application to the skin. Consequently, it
should be classified Corrosive, Cat. 1C.
Corrosive to eyes is assumed for
substances for which dermal corrosion has been established and no
additional classification is required.
There is no data from inhalation
studies. However, in view of the very low vapour pressure of AAI in
general, exposure by inhalation is not likely.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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