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EC number: 629-732-4
CAS number: 1224966-13-5
Assessment of acute oral toxicity with Tall
oil reaction products with tetraethylene-pentamine in the rat (Acute
Toxic Class Method).
The study was carried out based on the
guidelines described in:
- OECD No.423 (2001) "Acute Oral Toxicity,
Acute Toxic Class Method"
- Commission Regulation (EC) No 440/2008, B1
tris: "Acute Oral Toxicity, Acute Toxic Class Method"
- EPA, OPPTS 870.1100 (2002), "Acute Oral
- JMAFF guidelines (2000) including the most
recent partial revisions.
Initially, Tall oil reaction products with
tetraethylene-pentamine was administered by oral gavage to three female
Wistar rats at 300 mg/kg body weight. In a stepwise procedure additional
groups of females were dosed at 300 and 2000 mg/kg body weight. All
animals were subjected to daily observations and weekly determination of
body weight. Macroscopic examination was performed on the day of death
or after terminal sacrifice (Day 15).
One female at 2000 mg/kg was found dead on
Day 2. No mortality occurred among other animals at 2000 mg/kg, or among
animals at 300 mg/kg.
Clinical signs observed during the study
period were as follows:
Dose level Clinical signs
300 mg/kg Lethargy, hunched posture,
uncoordinated movements and/or piloerection on Day 1.
2000 mg/kg Hunched posture and/or
piloerection between Days 1 and 4.
The mean body weight gain shown by the
surviving animals over the study period was considered to be normal.
No abnormalities were found at macroscopic
post mortem examination of the animals.
The oral LD50 value of Tall oil reaction
products with tetraethylene-pentamine in Wistar rats was established to
exceed 2000 mg/kg body weight.
According to the OECD 423 test guideline,
the LD50 cut-off value was considered to be 2500 mg/kg body weight.
This study on Tall oil, reaction products
with tetraethylenepentamine is valid for the evaluation of AAI
substances for which higher ethyleneamines were used such as Tall oil
fatty acids, reaction products with polyethylenepolyamines
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