Registration Dossier
Registration Dossier
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EC number: 629-732-4 | CAS number: 1224966-13-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Endpoint summary
Administrative data
Description of key information
Additional information
Standard OECD 305 tests are technically not feasible with these strongly sorbing hydrolytically unstable substances. In addition is the route of exposure in a standard OECD 305 test unrealistic for these substances because the substance will either be sorbed or (bio)degraded. The bioaccumulation potential of the alkyl amidoamines/imidazolines was therefore assessed based on a measured log Kow.
As indicated before, alkyl amidoamines/imidazolines are hydrolyzed and biodegraded and it is therefore unlikely that they will accumulate in the food chain. Since there is a log Kow measured using the slow stirring method according to OECD 123, this value was used to predict the bioaccumulation potential. Based on this log Kow value of 2.2, the calculated log BCF is 1.24 (BCF = 17.4 EpiSuite v4.0).
Despite the fact that the log Kow is measured applying the most appropriate method according to the REACH guidance i.e. the slow stirring method (OECD 123), there is unfortunately no reliable relationship between the measured log Kow and BCF for this type of substances. The predicted low bioaccumulation potential is however supported by the low acute to chronic ratio observed in the long-term daphnia test.
The daphnia reproduction test result for e.g. DETA based imidazoline shows that at 810 μg nominal/L all parental daphnids were immobile within a few days, without reproduction, while at the next concentration of 270 µg nominal/L not only is there no immobilisation, but there is no detrimental effect on reproduction when compared to the control. These observations result in the derivation of a NOEC of 270 µg/L, resulting in a low acute-to-chronic ratio. A low acute-to-chronic ratio is indicative of a non-specific mode of action and is often associated with not systemic effects. This observation is consistent with the known effects of cationic surfactants on aquatic organisms, where toxicity is associated with physical binding to respiratory membranes. This explains the steep concentration curves seen and the lack of intermediate chronic effects on reproduction.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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