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EC number: 629-732-4
CAS number: 1224966-13-5
OECD 305 tests are technically not feasible with these strongly sorbing
hydrolytically unstable substances. In addition is the route of exposure
in a standard OECD 305 test unrealistic for these substances because the
substance will either be sorbed or (bio)degraded. The bioaccumulation
potential of the alkyl amidoamines/imidazolines was therefore assessed
based on a measured log Kow.
indicated before, alkyl amidoamines/imidazolines are hydrolyzed and
biodegraded and it is therefore unlikely that they will accumulate in
the food chain. Since there is a log Kow measured using the slow
stirring method according to OECD 123, this value was used to predict
the bioaccumulation potential. Based on this log Kow value of 2.2, the
calculated log BCF is 1.24 (BCF = 17.4 EpiSuite v4.0).
the fact that the log Kow is measured applying the most appropriate
method according to the REACH guidance i.e. the slow stirring method
(OECD 123), there is unfortunately no reliable relationship between the
measured log Kow and BCF for this type of substances. The predicted low
bioaccumulation potential is however supported by the low acute to
chronic ratio observed in the long-term daphnia test.
daphnia reproduction test result for e.g. DETA based imidazoline shows
that at 810 μg nominal/L all parental daphnids were immobile within a
few days, without reproduction, while at the next concentration of 270
µg nominal/L not only is there no immobilisation, but there is no
detrimental effect on reproduction when compared to the control. These
observations result in the derivation of a NOEC of 270 µg/L, resulting
in a low acute-to-chronic ratio. A low acute-to-chronic ratio is
indicative of a non-specific mode of action and is often associated with
not systemic effects. This observation is consistent with the known
effects of cationic surfactants on aquatic organisms, where toxicity is
associated with physical binding to respiratory membranes. This explains
the steep concentration curves seen and the lack of intermediate chronic
effects on reproduction.
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