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EC number: 629-732-4
CAS number: 1224966-13-5
All endpoints are based on measured data applying assessment factors,
with PNEC sediment calculated using the equilibrium partition
The PNECaquatic bulk is calculated using the assessment
factor proposed by the TGD. As long-term NOECs from
species representing two trophic levels are available (algae and
daphnia) an assessment factor of 50 may be used. Based on the observed
comparable or lower toxicity to fish for amidoamines/imidazolines it is
considered unlikely that fish toxicity will be critical for this
category of substances. In addition is the acute to chronic ratio for
daphnia small indicating no systemic effects. This observation is
consistent with the known effects of cationic surfactants on aquatic
organisms, where toxicity is associated with physical binding to
membranes. This explains the steep concentration curves seen and the
lack of intermediate chronic effects on reproduction.
Hence any additional toxicity testing with fish will not add scientific
value to the ecotoxicity profile of the amidoamines/imidazolines other
than for obtaining a lower assessment factor. It is therefore concluded
that for scientific reasons and in accordance to REACH legislation
further testing on fish has to be avoided for reasons of animal welfare.
This means that it is proposed to waive the long term fish unless a
further refinement of the effect assessment is considered necessary
based on the outcome of the chemical safety assessment.
For amidoamines/imidazolines a safety factor of 10 is applied for the
derivation of the PNECaquatic,bulk
to intrinsic properties of amine containing cationic surfactants river
water ecotoxicity tests deliver more reproducible test results with
limited uncertainty. As river water has a mitigating effect on
ecotoxicity due to sorption of the amines toand suspended matter a
factor of 10 should be applied to the L(E) C50to correct for
the lower ecotoxicity observed.
algae, daphnia and fish test results (Klimisch 1, 2 and 4) for the
72 h algae
ERC10/ NOEC (µg/L)
48 h daphnia
21 d daphnia
EC50corr(µg/L) (corrected for Classification with Factor 10)
EC10corr(µg/L) (corrected for Classification with Factor 10)
AAI-TEPA (Fatty acids C18 unsat, reaction products with tetraethylenepentamine)
amidoamines/imidazolines no ready biodegradability results have been
leads to the following environmental classification for
Acute aquatic hazard
H400 : Very toxic to aquatic life
M factor acute 10
aquatic hazard Chronic Category 1 H410: Very toxic to aquatic life with
M factor chronic
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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