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EC number: 629-732-4
CAS number: 1224966-13-5
Fatty acids C16-18, C18 unsat reaction
products with tetraethylenepentamine was found to be sensitising to skin
in a GPMT test.
This study on Fatty acids C16-18, C18 unsat
reaction products with tetraethylenepentamine is valid for the
evaluation of Tall oil fatty acids, reaction products with
All substances within the AAI group show the
same reactive groups, show similar composition of amide, imidazoline,
and some dimer structures of both, with the length of original EA amines
used for production as biggest difference. Inherent reactivity and
toxicity is not expected to differ much between these substances,
aspects which determine sensitization.
following information is available on sensitising properties of AAI
+ DETA Sensitising: 40% positive reaction in
GPMT, i.d. induction 0.1%
+ DETA Sensitising: LLNA: EC3: 0.3%.
C18 unsat + TEPA Sensitising: 100% positive
reaction in GPMT, i.d. induction 0.1%
+ Poly(Amide) Sensitising: 100% positive reaction in
GPMT, i.d. induction 0.2%
on the available data, all substances in the AAI group should be
considered sensitising to skin.
is no information on respiratory sensitisation, but AAI
products are sensitising to skin.
likelihood for exposure via inhalation and thus becoming sensitised to
AAI, is however very low, based on the high boiling point (> 300 °C) and
very low vapour pressure (0.00017 mPa at 25°C for DETA based AAI).
Various studies with different AAI indicate
that these substances can cause dermal sensitisation and
should be classified as dermal sensitiser Cat.1A for CLP (Criteria ATP
2, Commission Regulation 286/2011 of 10 March 2011).
The actual risk of sensitisation is probably
low, as AAI are corrosive to skin and consequently exposure will be low
due to necessary protetive measures to limit dermal exposure.
the likelihood for exposure via inhalation and thus becoming sensitised
to AAI, is very low, based on the high boiling point (> 300 °C) and very
low vapour pressure (0.00017 mPa at 25°C for DETA based AAI).
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