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EC number: 213-607-2 | CAS number: 993-13-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
An acute fish toxicity study according to OECD TG 203 was conducted with read across material MPAAU (Pupp 2012). The active substance caused no mortality to Fathead minnow (Pimephales promelas) after 96-hours exposure at the nominal concentration of 583 mg/L in a static test, and a nominal 96h-LC50 of 934.1 mg/L could be determined. Resulting from an acute Daphnia toxicity study (Kamp 1995) with read across substance MPAAU according to OECD-Test Guideline 202, the EC50 value was calculated as being 350 mg/L for the active substance. An algal growth inhibition study (Kley 2012) with read across substance MPAAU revealed following results for growth rate: 72h-EC50 = 43.1 mg/L, 72h-EC10 = 13.5 mg/L, 72h-NOEC value = 3.2 mg/L. Therefore, the algae should be considered as the most sensitive of the tested freshwater organisms. Information on long-term toxicity for fish and daphnids is currently not available.
The L(E)C50 values are based on studies on MPAAU and so the actual concentration of MPA needs to be determined. MPAAU is a composed of 1 part MPA and 1 part AU. Using the molecular weight of each substance the nominal concentration of MPA in the study can be determined and the endpoint for MPA determined accordingly. Converting a weight/weight concentration of MPAAU into a weight/weight concentration of MPA the molecular weight of MPA has to be divided by the molecular weight of MPAAU. The molecular weight of MPA is 96. The molecular weight of MPA is 198. 96/198 = 0.48. Therefore the relevant endpoint value for a study on MPAAU can be multiplied by a factor of 0.48 to determine to endpoint value for MPA.
The EC50 for algal growth inhibition 43.1 mg/L is for MPAAU and therefore the EC50 for MPA can reduced to 21.6 mg/L (EC10 = 6.75 mg/L, NOEC = 1.6 mg/L). In the same way the LC50 for fish can be calculated to 467 mg/L, and for Daphnia 175 mg/L.
In a valid, reliable and conclusive study according to OECD TG 209 (2010), the effect of the test item Methyl phosphonic acid 70 % on the respiration of activated sewage sludge micro-organisms gave a 3-Hour EC50 value of greater than 1000 mg ai/L. The No Observed Effect Concentration (NOEC) after 3 hours exposure was 100 mg ai/L.
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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