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Ecotoxicological information

Short-term toxicity to fish

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Endpoint:
short-term toxicity to fish
Type of information:
experimental study
Adequacy of study:
weight of evidence
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
secondary literature
Qualifier:
no guideline followed
Principles of method if other than guideline:
No details on test method provided.
GLP compliance:
not specified
Test organisms (species):
other: bluegill sunfish (species not defined)
Duration:
96 h
Dose descriptor:
LC50
Effect conc.:
12.38 mg/L
Conclusions:
The 96h LC50 of MPA to bluegill sunfish was reported to be 12.38 mg/L.
Endpoint:
short-term toxicity to fish
Type of information:
experimental study
Adequacy of study:
weight of evidence
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
secondary literature
Qualifier:
no guideline followed
Principles of method if other than guideline:
No data on test method provided.
GLP compliance:
not specified
Analytical monitoring:
not specified
Vehicle:
not specified
Test organisms (species):
other: fathead minnow (species not defined)
Test type:
not specified
Water media type:
not specified
Total exposure duration:
96 h
Duration:
96 h
Dose descriptor:
LC50
Effect conc.:
10.617 mg/L
Conclusions:
The 96h LC50 of MPA to fathead minnow was reported to be 10.617 mg/L.

Description of key information

A nominal 96h-LC50 of 934.1 mg/l could be determined with read across substance MPAAU.

Key value for chemical safety assessment

LC50 for freshwater fish:
934.1 mg/L

Additional information

A valid fish acute toxicity study according to OECD TG 203 was conducted with read across material MPAAU (Pupp 2012). The active substance caused no mortality to Fathead minnow (Pimephales promelas) after 96-hours exposure to a nominal concentration of 583 mg/L in a static test, and a nominal 96h-LC50 of 934.1 mg/l could be determined.

The two studies with bluegill sunfish and Fathead Minnows of Williams 1987 were conducted with the target substance itself.

However, the review article of Munro et al. (1999) is giving no further information than the mere result. But these data only are known from this single secondary literature source, it is furthermore not possible to verify the correctness of the data by a second independent data source. Because of this, further attempts were undertaken to retrieve the original study report from U.S. military web services (USCEHR, NTIS), but unfortunately without success.

With no further clarification on data reliability possible, this renders the reliability of the two acute fish toxicity studies of Williams (1987) as not assignable (Klimisch 4).