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Ecotoxicological information

Short-term toxicity to aquatic invertebrates

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Reference
Endpoint:
short-term toxicity to aquatic invertebrates
Type of information:
experimental study
Adequacy of study:
weight of evidence
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
secondary literature
Qualifier:
no guideline followed
Principles of method if other than guideline:
No details on test method provided.
GLP compliance:
not specified
Analytical monitoring:
not specified
Vehicle:
not specified
Test organisms (species):
Daphnia magna
Test type:
not specified
Water media type:
not specified
Total exposure duration:
48 h
Duration:
48 h
Dose descriptor:
LC50
Effect conc.:
3.273 mg/L
Conclusions:
The 48h EC50 of MPA to Daphnia magna was reported to be 3.273 mg/L.

Description of key information

The EC50 value (48 hours) for Daphnia magna is 700 mg test item/L. Therefore the EC50 values for the active substance can be calculated for 24h with 390 mg/L and for 48h with 350 mg/L.

Key value for chemical safety assessment

EC50/LC50 for freshwater invertebrates:
350 mg/L

Additional information

Resulting from a valid acute Daphnia toxicity study (Kamp 1995) with read across substance MPAAU according to OECD-Test Guideline 202 the EC50 values were calculated as being 780 and 700 mg test item/L measured after 24h and 48h, respectively. Therefore, the EC50 values for the active substance can be calculated for 24h with 390 mg/L and for 48h with 350 mg/L.

The acute Daphnia study of Williams 1987 was conducted with the target substance itself.

However, the review article of Munro et al. (1999) is giving no further information than the mere result. But these data only are known from this single secondary literature source, it is furthermore not possible to verify the correctness of the data by a second independent data source. Because of this, further attempts were undertaken to retrieve the original study report from U.S. military web services (USCEHR, NTIS), but unfortunately without success.

With no further clarification on data reliability possible, this renders the reliability of the acute Daphnia toxicity study of Williams (1987) as not assignable (Klimisch 4).