Registration Dossier

Toxicological information

Skin sensitisation

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Administrative data

Endpoint:
skin sensitisation
Remarks:
other: calculations of dermal exposure limits
Type of information:
migrated information: read-across from supporting substance (structural analogue or surrogate)
Adequacy of study:
supporting study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Read-across to soluble chromates. Acceptable study report which follows basic scientific principles.

Data source

Reference
Reference Type:
publication
Title:
Nickel, chromium and cobalt in consumer products: revisiting safe levels in the new millennium.
Author:
Basketter D, Angelini G. et al.
Year:
2003
Bibliographic source:
Contact Dermatitis 49, 1-7

Materials and methods

Test guideline
Qualifier:
no guideline followed
Principles of method if other than guideline:
Calculation of dermal exposure limits based on LLNA results
GLP compliance:
no
Type of study:
other: calculation of dermal exposure limits based on LLNA results

Test material

Reference
Name:
Unnamed
Type:
Constituent

Results and discussion

Applicant's summary and conclusion

Interpretation of results:
sensitising
Remarks:
Migrated information
Conclusions:
The report determined the NOEL for potassium dichromate skin sensitisation. Based on the NOEL and justified uncertainty factors, the acceptable dermal exposure level for chromium in consumer products was calculated. The NOEL was 1 µg Cr/cm2 8Based on EC3=0.058%) and the suggested maximum human exposure limit (S-Rfd) for consumer products was 0.01 µg/cm2 Cr.
Executive summary:

The report of Basketter et al. (2003) determined the NOEL for potassium dichromate skin sensitisation. Based on the NOEL and justified uncertainty factors, the acceptable dermal exposure level for chromium in consumer products was calculated. The NOEL was 1 µg Cr/cm2 and the suggested maximum human exposure limit (S-Rfd) for consumer products was 0.01 µg/cm2 Cr.