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Toxicological information

Acute Toxicity: other routes

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Administrative data

Endpoint:
acute toxicity: other routes
Type of information:
migrated information: read-across from supporting substance (structural analogue or surrogate)
Adequacy of study:
weight of evidence
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Read-across from a sparingly water soluble chromate and from a highly water soluble chromate. Not a guideline or GLP study.
Cross-reference
Reason / purpose:
reference to same study

Data source

Reference
Reference Type:
publication
Title:
Toxicokinetics of hexavalent chromium in the rat after intratracheal administration of chromates of different solubilities.
Author:
Bragt, P. C. and E. A. van Dura
Year:
1983
Bibliographic source:
Ann Occup Hyg.27(3): 315-22.

Materials and methods

Principles of method if other than guideline:
kinetics in the rat after a single intratracheal dose of a substance
GLP compliance:
not specified

Test material

Reference
Name:
Unnamed
Type:
Constituent

Test animals

Species:
rat
Strain:
Wistar
Sex:
male
Details on test animals and environmental conditions:
TEST ANIMALS
- Weight at study initiation: 165-200 g
- Housing: individually in stainless steel metabolic cages
- Diet (e.g. ad libitum): standard pellet diet (Hope Farms, Woerden, the Netherlands)
- Water (e.g. ad libitum): ad libidum

Administration / exposure

Route of administration:
other: intratracheal
Details on exposure:
The animals were anaesthesised during injection.
Doses:
20 ul solution or suspension of either sodium chromate (69 ug Cr), zinc chromate (66 ug Cr) or lead chromate (38 ug Cr) in saline containing 0.4-6.0 uCi 51Cr;

Results and discussion

Any other information on results incl. tables

Zinc chromate caused macroscopically visible haemorrhages and exudation of the lungs within 24 h after its administration, resulting in irregular and halting breathing. These symptoms disappeared on day 6.

Applicant's summary and conclusion

Executive summary:

Bragt and van Dura (1983) studied the kinetics of chromium in the rat after a single intratracheal dose of sodium, zinc or lead51Cr-chromate. The rats received a 20 μl solution or suspension of either sodium chromate (69 μg Cr), zinc chromate (66 μg Cr) or lead chromate (38 μg Cr). Intratracheal instillation of sparingly water-soluble zinc chromate produced irregular breathing and lung haemorrhage and oedema at 24 hours in male Wistar rats.