Registration Dossier

Toxicological information

Sensitisation data (human)

Currently viewing:

Administrative data

Endpoint:
sensitisation data (humans)
Type of information:
migrated information: read-across from supporting substance (structural analogue or surrogate)
Adequacy of study:
weight of evidence
Reliability:
other: evaluation
Rationale for reliability incl. deficiencies:
other: Three evaluations of available reports on respiratory sensitisation and occupational asthma cases.

Data source

Referenceopen allclose all

Reference Type:
other: evaluation
Title:
Chromium trioxide, sodium chromate, sodium dichomate, ammonium dichromate and potassium dichromate, risk assessment
Author:
EU
Year:
2005
Bibliographic source:
European Chemicals Bureau, Institute for Health and Consumer Production
Reference Type:
other: evaluation
Title:
Toxicity review 21. The toxicity of chromium and inorganic chromium compounds.
Author:
Fairhurst, S. and C. A. Minty
Year:
1989
Bibliographic source:
Health and Safety Executive, Merseyside, UK.
Reference Type:
other: evaluation
Title:
Criteria Document for Hexavalent Chromium.
Author:
Cross, H. J., S. P. Faux, et al.
Year:
1997
Bibliographic source:
Commissioned by International Chromium Development Association (ICDA), Paris, France; .

Materials and methods

Type of sensitisation studied:
respiratory
Study type:
other: evaluations on available data
Principles of method if other than guideline:
Three reliable, independent evaluations examining available data on chromium-induced respiratory sensitisation.
GLP compliance:
no

Test material

Reference
Name:
Unnamed
Type:
Constituent
Details on test material:
Evaluations of reports on chromium(VI).

Method

Type of population:
occupational

Results and discussion

Results of examinations:
The evaluations concluded that asthma caused by exposure to chromium(VI) was suggested already in the 19th century.
Case reports and confirmations received in bronchial challenge tests show that Cr(VI) inhalation is likely to cause occupational asthma. It was also mentioned that Cr(VI) sensitised persons may also have reactions after Cr(III) exposure. The EU RAR concluded that based on available data, a no-effect level or exposure-response relationship cannot be determined for induction or elicitation of occupational asthma.

Applicant's summary and conclusion

Conclusions:
Case reports and confirmations received in bronchial challenge tests show that Cr(VI) inhalation is likely to cause occupational asthma.Cr(VI) sensitised persons may also have reactions after Cr(III) exposure. The EU RAR concluded that based on available data, a no-effect level or exposure-response relationship cannot be determined for induction or elicitation of occupational asthma.
Executive summary:

Three reliable, independent evaluations examined available data on chromium-induced respiratory sensitisation (EU 2005, Cross et al 1997, Fairhurst and Minty 1989). The evaluations concluded that asthma caused by exposure to chromium(VI) was suggested already in the 19th century. Case reports and confirmations received in bronchial challenge tests show that Cr(VI) inhalation is likely to cause occupational asthma. It was also mentioned that Cr(VI) sensitised persons may also have reactions after Cr(III) exposure. The EU RAR concluded that based on available data, a no-effect level or exposure-response relationship cannot be determined for induction or elicitation of occupational asthma.