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Toxicological information

Health surveillance data

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Administrative data

Endpoint:
health surveillance data
Type of information:
migrated information: read-across from supporting substance (structural analogue or surrogate)
Adequacy of study:
supporting study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Read-across to Cr(VI) exposure. Acceptable study report.

Data source

Reference
Reference Type:
publication
Title:
Risk for reduced sperm quality among metal workers, with special reference to welders.
Author:
Mortensen, J. T.
Year:
1988
Bibliographic source:
Scand J Work Environ Health.14(1): 27-30.

Materials and methods

Study type:
medical monitoring
Endpoint addressed:
toxicity to reproduction / fertility
Test guideline
Qualifier:
no guideline followed
Principles of method if other than guideline:
The purpose of the study was to investigate whether men emplyed in the metal industry had poorer sperm quality than men in other type of work. Semen analysis was performed and basic data was collected in a questionnaire.
GLP compliance:
no

Test material

Reference
Name:
Unnamed
Type:
Constituent
Details on test material:
No details available.

Method

Type of population:
occupational
Ethical approval:
not specified
Details on study design:
The purpose of the study was to investigate whether men emplyed in the metal industry had poorer sperm quality than men in other type of work. Semen analysis was performed and basic data was collected in a questionnaire. The study population consisted of 3119 men who, in connection with fertility problems, had delivered a semen sample to one of the hospitals in Aalborg, Aarhus, Soenderborg or Odense (Denmark). In December 1984 a postal questionnaire was sent out to the participants.
Based on the occupational information in the quiestionnaires, the men were grouped as welders, metalworkers not exposed to welding, other industrial workers, or unexposed workers. The sperm quality was analysed and the risk for poor sperm quality in the different groups was calculated.

Results and discussion

Results:
The study results revealed that relative risk of reduced sperm quality was greater among welders than among non-welding metalworkers or other industrial workers.

Applicant's summary and conclusion

Conclusions:
The study results revealed that relative risk of reduced sperm quality was greater among welders than among non-welding metalworkers or other industrial workers.
Executive summary:

Occupational information on males examined at infertility clinics revealed that relative risk of reduced sperm quality was greater among welders than among non-welding metalworkers or other industrial workers

(Mortensen 1988)

. No exposure data were presented in the report .