Registration Dossier

Administrative data

Endpoint:
acute toxicity: dermal
Type of information:
migrated information: read-across from supporting substance (structural analogue or surrogate)
Adequacy of study:
weight of evidence
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Read-across from highly water soluble chromates. Comparable to guideline study. Symposium paper.
Cross-reference
Reason / purpose:
reference to same study

Data source

Reference
Reference Type:
secondary source
Title:
Acute toxicity of chromate salts
Author:
Gad, S. C., B. J. Dunn, et al.
Year:
1986
Bibliographic source:
Serrone D. editor: Proceedings of Chromium Symposium 1986: an update., Industrial Health Foundation.

Materials and methods

Principles of method if other than guideline:
a standard set of protocol for acute dermal toxicity
GLP compliance:
not specified

Test material

Reference
Name:
Unnamed
Type:
Constituent
Details on test material:
- Name of test material (as cited in study report): sodium chromate, sodium dichromate, potassium dichromate, ammonium dichromate

Test animals

Species:
rabbit
Strain:
New Zealand White
Sex:
male/female
Details on test animals and environmental conditions:
TEST ANIMALS
- Source: Summit View Farms, Bellvidere, New Jersey
- Housing: individually in suspended stainless steel cages with wire mesh on the front and bottom
- Diet (e.g. ad libitum): Purina Rodent Chow No. 5001 ad libidum
- Water (e.g. ad libitum): ad libidum
- Acclimation period: quarantined for at least two weeks prior to study

ENVIRONMENTAL CONDITIONS
- Temperature (°C): 72+-2 F
- Humidity (%): 50+-5
- Photoperiod (hrs dark / hrs light): 12/12

Administration / exposure

Details on dermal exposure:
The test substance was applied to the skin and wetted with an equivalent amount of physiological saline.
Duration of exposure:
24 h
Doses:
1.5 and 2.0 g/kg of sodium chromate; 1.0, 1.5 and 2.0 g/kg of sodium dichromate, of potassium dichromate or of ammonium dichromate
No. of animals per sex per dose:
5 M / 5 F
Control animals:
yes

Results and discussion

Effect levelsopen allclose all
Sex:
male/female
Dose descriptor:
LD50
Effect level:
1.6 other: g/kg
Remarks on result:
other: sodium chromate
Sex:
male/female
Dose descriptor:
LD50
Effect level:
1 other: g/kg
Remarks on result:
other: sodium dichromate
Sex:
male/female
Dose descriptor:
LD50
Effect level:
1.17 other: g/kg
Remarks on result:
other: potassium dichromate
Sex:
male/female
Dose descriptor:
LD50
Effect level:
1.64 other: g/kg
Remarks on result:
other: ammonium dichromate

Applicant's summary and conclusion

Interpretation of results:
relatively harmless
Remarks:
Migrated information Criteria used for interpretation of results: OECD GHS
Conclusions:
LD50s of highly water soluble chromates fall into category 4 'harmful in contact with skin'. This data is not suggested to be used as such in the classification of sparingly water soluble strontium chromate (dermal absorption of <1% for water soluble chromate has been identified and sparingly soluble chromates may be even less effective on skin; judgement for strontium chromate is thus 'no classification').
Executive summary:

Gad et al. (1986) studied sodium chromate, sodium dichromate, potassium dichromate and ammonium dichromate by a standard set of protocols for acute inhalation by dermal route. In a single 24 hour dermal exposure, rabbits (5 males and 5 females in each group) were exposed to the following chromium salt doses: 1.5 and 2.0 g/kg for sodium chromate, 1.0, 1.5 and 2.0 g/kg for sodium dichromate, 1.0, 1.5 and 2.0 g/kg for potassium dichromate, and 1.0, 1.5 and 2.0 g/kg for ammonium dichromate.

Numerous clinical observations were seen with all test compounds and both sexes, such as dermal necrosis, eschar formation, dermal corrosion, diarrhea, hypoacitivity and dermal edema and erythema.Single-dose dermal LD50values in rabbits exposed to chromium(VI) as chromium salts ranged from 1.03 g/kg for sodium dichromate to 1.73 g/kg for sodium chromate in females and from 0.96 g/kg for sodium dichromate to 1.86 g/kg for ammonium dichromate in males.