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Toxicological information

Eye irritation

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Administrative data

Endpoint:
eye irritation: in vivo
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: No OECD guideline or GLP defined, acceptable restrictions (incomplete documentation).
Cross-reference
Reason / purpose:
reference to same study

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1971
Report Date:
1971

Materials and methods

Test guideline
Qualifier:
equivalent or similar to
Guideline:
OECD Guideline 405 (Acute Eye Irritation / Corrosion)
Deviations:
yes
Remarks:
, only 0.05 mL applied, no 48 and 72 hour observation
Principles of method if other than guideline:
Other: single application of 50 mm³ undiluted test substance into the eye of a rabbit, observation time: 8 d (no further information).
GLP compliance:
no

Test material

Reference
Name:
Unnamed
Type:
Constituent
Test material form:
other: liquid
Details on test material:
- Name of test material: Benzylamin

Test animals / tissue source

Species:
rabbit
Strain:
Vienna White
Details on test animals or tissues and environmental conditions:
TEST ANIMALS
- Weight at study initiation: 3.25 and 3.43 kg

Test system

Vehicle:
unchanged (no vehicle)
Controls:
other: The NaCl-treated adjacent eye served as control.
Duration of treatment / exposure:
Single application of 50 mm³ undiluted test substance into the eye of a rabbit.
Observation period (in vivo):
8 d (scoring at 1 hour, 24 hours and 8 days)
Number of animals or in vitro replicates:
2

Results and discussion

In vivo

Irritant / corrosive response data:
Both treated animals showed corrosion of the eye after 1 h, additionally edema after 24 h and purulence after 8 d. No irritant or corrosive response was observed in the control eyes.

Any other information on results incl. tables

At BASF’s Department of Toxicology, acute toxicity testing was performed according to published methods, which were adapted and standardized for the specific needs of the company, well before Test Guidelines for these methods were established by the OECD beginning 1982. These methods were comparable to the Union Carbide (now a DOW company) range finding toxicity data which have been published in the early toxicological literature (1944-1949). The results of these studies were reported until the early 1980s in summary reports called „Ergebnis der gewerbetoxikologischen Vorprüfung“ or „Toxikologische Grundprüfung“, which do not present details of the methods used, but focus on a summary presentation of the results.

Applicant's summary and conclusion

Interpretation of results:
highly corrosive
Remarks:
Migrated information Criteria used for interpretation of results: EU