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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Skin sensitisation

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Administrative data

Endpoint:
skin sensitisation
Remarks:
in vivo
Type of information:
experimental study
Adequacy of study:
other information
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
other: No GLP defined. Cross reactivity with other substance investigated.

Data source

Reference
Reference Type:
publication
Title:
Unnamed
Year:
1990

Materials and methods

Principles of method if other than guideline:
Method: other: In a skin sensitisation study in 4 human volunteers, 1 % benzylamine in vaseline was applied to the back, covered with a plaster. The exposition time was 24 h and the reading took place after 24, 48 and 72 h post exposure. 4 Patients with allergic contact dermatitis due to m-Xylylene diamine revealed allergic cross reactions to benzylamine.
GLP compliance:
no
Type of study:
other: epicutaneous test

Test material

Constituent 1
Reference substance name:
100-46-7
IUPAC Name:
100-46-7
Details on test material:
- Name of test material: Benzylamine

In vivo test system

Test animals

Species:
human
Strain:
not specified
Sex:
not specified

Study design: in vivo (non-LLNA)

Inductionopen allclose all
Route:
other: epicutaneous, covered with a plaster (no further information)
Vehicle:
no data
Concentration / amount:
no data
Challengeopen allclose all
Route:
epicutaneous, occlusive
Vehicle:
no data
Concentration / amount:
no data
No. of animals per dose:
4 humans

Results and discussion

Any other information on results incl. tables

Four patients with allergic contact dermatitis due to m-Xylylene diamine revealed allergic cross reactions to benzylamine.

Applicant's summary and conclusion