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Toxicological information

Direct observations: clinical cases, poisoning incidents and other

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Administrative data

Endpoint:
direct observations: clinical cases, poisoning incidents and other
Type of information:
other: case report
Adequacy of study:
other information
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
other: No OECD guideline or GLP defined. Several substances tested.

Data source

Reference
Reference Type:
publication
Title:
Unnamed
Year:
1984

Materials and methods

Study type:
other: Patch test
Endpoint addressed:
skin sensitisation
Principles of method if other than guideline:
Method: other: testing in concentrations of 0.1 % and 1.0 % in ethanol (70 %), 10 control persons. During a period of one year, a48-year-old chemist was doing some experimental work to produce game-tocides for the prevention of cross pollination in the agricultural industry. he was working with some intermediate products including epichlorhydrin, benzylamine and benzyl-1-amino-3 chloro-2-hydroxy-propane. Shortly after contact with these materials, he developed a dermatitis of both hands and face. After stopping his work, the dermatitis subsided within a few days. he had an atopic constitution with a history of hay fever. Intracutaneous tests to some inhalants including house-dust, grass polen and animal dender were positive. reactions to patch tests with the ICDRG series, including epoxy resin, showed weak reaktion to formaldehyde. patch tests to epichlorhydrine 0.01% and 0.1% in acetone were negative. However, the reactions to benzylamine and benzyl-1-amino-3 chloro-2-hydroxypropane were positive. Both materials dissolved in ethanol 70% were tested in concentrations of 0.1% and 1%. 10 control persons showed negative reactions to these chemicals.Although benzylamine is known as a strong irritant, the reactions to benzylamine and benzyl-1-amino-3 chloro-2-hydroxypropane may be considered as allergic reactions. The positive reactions are probably a manifestion of cross-sensitivity.
GLP compliance:
not specified

Test material

Reference
Name:
Unnamed
Type:
Constituent
Details on test material:
- Name of test material: Benzylamine

Results and discussion

Any other information on results incl. tables

Case report: During a period of one year, a 48-year-old chemist was doing some experimental work to produce game-tocides for the prevention of cross pollination in the agricultural industry. he was working with some intermediate products including epichlorhydrin, benzylamine and benzyl-1-amino-3 chloro-2-hydroxy-propane. Shortly after contact with these materials, he developed a dermatitis of both hands and face. After stopping his work, the dermatitis subsided within a few days. he had an atopic constitution with a history of hay fever. Intracutaneous tests to some inhalants including house-dust, grass polen and animal dender were positive. reactions to patch tests with the ICDRG series, including epoxy resin, showed weak reaktion to formaldehyde. patch tests to epichlorhydrine 0.01% and 0.1% in acetone were negative. However, the reactions to benzylamine and benzyl-1-amino-3 chloro-2-hydroxypropane were positive. Both materials dissolved in ethanol 70% were tested in concentrations of 0.1% and 1%. 10 control persons showed negative reactions to these chemicals.Although benzylamine is known as a strong irritant, the reactions to benzylamine and benzyl-1-amino-3 chloro-2-hydroxypropane may be considered as allergic reactions. The positive reactions are probably a manifestion of cross-sensitivity.

Applicant's summary and conclusion