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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Acute Toxicity: oral

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Administrative data

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: No OECD guideline or GLP defined, acceptable restrictions (incomplete documentation).
Cross-reference
Reason / purpose for cross-reference:
reference to same study

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1977
Report date:
1977

Materials and methods

Test guideline
Qualifier:
equivalent or similar to guideline
Guideline:
OECD Guideline 401 (Acute Oral Toxicity)
Principles of method if other than guideline:
other: 10 males, single oral application by gavage of undiluted test substance, observation time: 14 d
GLP compliance:
no
Test type:
standard acute method
Limit test:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
Benzylamine
EC Number:
202-854-1
EC Name:
Benzylamine
Cas Number:
100-46-9
Molecular formula:
C7H9N
IUPAC Name:
1-phenylmethanamine
Test material form:
other: liquid
Details on test material:
- Name of test material: Benzylamin

Test animals

Species:
rat
Strain:
Wistar
Sex:
male
Details on test animals or test system and environmental conditions:
TEST ANIMALS
- Source: Winkelmann
- Weight at study initiation: 160 - 180 g

Administration / exposure

Route of administration:
oral: gavage
Vehicle:
unchanged (no vehicle)
Doses:
0.8; 1.0; 1.2; 1.3; 1.5 mL/kg bw
No. of animals per sex per dose:
10
Control animals:
no
Details on study design:
- Duration of observation period following administration: 14 days
- Necropsy of survivors performed: no
Statistics:
LD50 calculation according to Fink and Hund.

Results and discussion

Effect levels
Sex:
male
Dose descriptor:
LD50
Effect level:
ca. 1.15 mL/kg bw
Based on:
test mat.
95% CL:
1.05 - 1.25
Remarks on result:
other: corresponding to 1127 mg/kg bw
Mortality:
1.5 mL/kg bw: 10/10;
1.3 mL/kg bw: 6/10;
1.2 mL/kg bw: 6/10;
1.0 mL/kg bw: 3/10;
0.8 mL/kg bw: 0/10
Clinical signs:
other: Diarrhea, sedation, respiratory disorders and tonical cramps.

Any other information on results incl. tables

The LD50 of 1.15 mL/kg bw corresponds to approx. 1127 mg/kg bw.

Applicant's summary and conclusion