Registration Dossier

Administrative data

Endpoint:
sensitisation data (humans)
Type of information:
experimental study
Adequacy of study:
other information
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
other: No GLP defined. Cross reactivity with other substance investigated.

Data source

Reference
Reference Type:
publication
Title:
Unnamed
Year:
1990

Materials and methods

Type of sensitisation studied:
skin
Study type:
study with volunteers
Principles of method if other than guideline:
Method: other: 1 % benzylamine in vaseline to the back, covered with a plaster, exposition time 24 h, reading 24, 48, 72 h post exposure
GLP compliance:
not specified

Test material

Reference
Name:
Unnamed
Type:
Constituent
Details on test material:
- Name of test material: Benzylamine

Method

Type of population:
occupational
Controls:
no data
Route of administration:
dermal

Results and discussion

Any other information on results incl. tables

Method: other: 1 % benzylamine in vaseline to the back, covered with a plaster, exposition time 24 h, reading 24, 48, 72 h post exposure

Applicant's summary and conclusion

Executive summary:

In a skin sensitisation study in 4 human volunteers, 1 % benzylamine in vaseline was applied to the back, covered with a plaster. The exposition time was 24 h and the reading took place after 24, 48 and 72 h post exposure. 4 Patients with allergic contact dermatitis due to m-Xylylene diamine revealed allergic cross reactions to benzylamine.