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EC number: 700-869-2
CAS number: -
INTERPRETATION OF RESULTS
According to EU classification, the irritancy potential of test
substances is predicted for distinguish between R38 skin irritating and
no-label (non skin irritating) test substance OECD 404 and Regulation
(EC) No 1272/2008. In this study the irritancy potential of test
substances is predicted by mean tissue viability of tissues exposed to
the test substance.
The test substance is considered to be irritant to skin (R38), if
the mean relative viability after 42 minutes exposure and 42 hours post
incubation is less or equal to 50% of the negative control.
The negative control data meet the acceptance criteria if the mean
OD value of the 3 tissues at 570 nm is:
1.2 ≤ OD ≤ 2.5
The positive control data meet the acceptance criteria if the mean
viability, expressed as % of the NC, is ≤ 40%.
In both case, the standard deviation value will be considered
valid if it is ≤ 18% according to the performance standard (ECVAM SIVS,
Optic density (OD) at 570nm
1.2 ≤ OD ≤ 2.5
< 40 %
The eye irritancy potential of CarboNeXT was invistigated in the bovine
corneal opacity and permeability assay.
The test item was diluted with physiological saline 0.9% NaCl to gain a
The following mean in vitro score was calculated: 2.88
Therefore the test item was classified as non irritant.
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