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EC number: 216-407-3
CAS number: 1576-35-8
No testing data on skin sensitisation available for TSH.
Using different QSAR models, no valid prediction could be made. Only one model predicted TSH to have skin sensitising properties, but this prediction was with low reliability.
The presumed breakdown product of Toluene-4-sulphonohydrazid (TSH), hydrazine (CAS No. 302-01-2), is officially recognized in the EU as a skin sensitizing compound and has a harmonized classification for Skin Sens. 1 (H317). When applied to skin, TSH is expected to slowly hydrolyse to hydrazine due to the moisture in the skin. A small amount of hydrazine may be generated and could induce skin sensitisation.
Therefore, as a precautious approach TSH is classified accordingly as a skin sensitiser (Skin Sens. 1 (H317).
No testing data on skin sensitisation is available for Toluene-4-sulphonohydrazid (TSH).
Form QSAR prediction on skin sensitisation using the Danish QSAR database (see attached prediction report), no valid prediction could be derived using a battery approach (3 seperate predictions from CASE Ultra, Leadscope and SciQSAR). The predictions for skin sensitisation and irritation in animal models (Guinea pig and rabbit) was outside applicability domain. Further, in the same prediction report from the Danish QSAR database, no alert for protein binding and potency estimation was found using different models (OASIS, OECD QSAR Toolbox, DRPA).
Prediction on skin sensitisation of TSH using the QSAR Vega tool (CAESAR model) revealed a positive prediction but with low reliability score (see attached prediction report).
Also, using the Toxtree programme, no alrets was identified for skin sensitisastion.
Based on the overall dataset from different in silico prediction models (Danish QSAR database, QSAR Vega, ToxTree; OECD QSAR Toolbox) no valid conclusion can be derived for skin sentisation of TSH.
The presumed breakdown product of Toluene-4-sulphonohydrazid (TSH), hydrazine (CAS No. 302-01-2), is officially recognized in the EU as a skin sensitizing compound and has a harmonized classification for Skin Sens. 1 (H317). When applied to skin, TSH is expected to slowly hydrolyse to hydrazine due to the moisture in the skin. A small amount of hydrazine may be generated and could induce skin sensitisatin.
Thus, a precautinary approach would be to consider TSH as a skin sensitiser and classify accordingly (Skin Sens. 1 (H317).
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