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Diss Factsheets

Administrative data

Endpoint:
acute toxicity: oral
Type of information:
(Q)SAR
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
results derived from a valid (Q)SAR model and falling into its applicability domain, with limited documentation / justification
Justification for type of information:
No data is available for Toluene-4-sulphonohydrazide (TSH). However, QSAR prediction data shows that oral LD50 in rats and mice is 320 mg/kg bw/day and 1300 mg/kg bw/day, respectively. The predictions had a moderate prediction quality i.e., 0.59 and 0.52 for rats and mice, respectively.

Data source

Reference
Reference Type:
other: Q(SAR) prediction report
Title:
(Q)SAR predicted profile for toluene-4-sulphonohydrazide
Year:
2022
Bibliographic source:
Danish Q(SAR) database
Report date:
2022

Materials and methods

Principles of method if other than guideline:
- Software tool(s) used including version: Danish Q(SAR) database

Test material

Constituent 1
Chemical structure
Reference substance name:
Toluene-4-sulphonohydrazide
EC Number:
216-407-3
EC Name:
Toluene-4-sulphonohydrazide
Cas Number:
1576-35-8
Molecular formula:
C7H10N2O2S
IUPAC Name:
toluene-4-sulphonohydrazide
Test material form:
solid: particulate/powder

Administration / exposure

Route of administration:
oral: gavage
Vehicle:
not specified

Results and discussion

Preliminary study:
Rat Oral LD50 predicted to be 320 mg/kg bw/day. Reliability index of 0.59 (moderate prediction quality)
Effect levels
Key result
Sex:
not specified
Dose descriptor:
LD50
Effect level:
320 mg/kg bw

Applicant's summary and conclusion

Interpretation of results:
Category 3 based on GHS criteria
Remarks:
LD50 from 250 to 320 mg/kg bw
Executive summary:

No data is available for Toluene-4-sulphonohydrazide (TSH). However, QSAR prediction data shows that oral LD50 in rats and mice is 320 mg/kg bw/day and 1300 mg/kg bw/day, respectively. The predictions had a moderate prediction quality i.e., 0.59 and 0.52 for rats and mice, respectively.


In suppport, data from a recent study conducted according to OECD guideline 489 (in vivo mammalian alkaline comet assay) where Wister rats were treated by oral gavage with the Toluene-4-sulphonohydrazide, mortality was observed at a dose of 250 mg/kg 02.bw/day in males.Based on this TSH should be classified as Acute tox 3