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EC number: 216-407-3
CAS number: 1576-35-8
No data is available for Toluene-4-sulphonohydrazide (TSH). However, QSAR prediction data shows that oral LD50 in rats and mice is 320 mg/kg bw/day and 1300 mg/kg bw/day, respectively. The predictions had a moderate prediction quality i.e., 0.59 and 0.52 for rats and mice, respectively.
In suppport, data from a recent study conducted according to OECD guideline 489 (in vivo mammalian alkaline comet assay) where Wister rats were treated by oral gavage with the Toluene-4-sulphonohydrazide, mortality was observed at a dose of 250 mg/kg 02.bw/day in males.Based on this TSH should be classified as Acute tox 3
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