Registration Dossier

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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Endpoint:
acute toxicity: oral
Type of information:
(Q)SAR
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
results derived from a valid (Q)SAR model and falling into its applicability domain, with limited documentation / justification
Justification for type of information:
No data is available for Toluene-4-sulphonohydrazide (TSH). However, QSAR prediction data shows that oral LD50 in rats and mice is 320 mg/kg bw/day and 1300 mg/kg bw/day, respectively. The predictions had a moderate prediction quality i.e., 0.59 and 0.52 for rats and mice, respectively.

Data source

Reference
Reference Type:
other: Q(SAR) prediction report
Title:
(Q)SAR predicted profile for toluene-4-sulphonohydrazide
Year:
2022
Bibliographic source:
Danish Q(SAR) database
Report date:
2022

Materials and methods

Principles of method if other than guideline:
- Software tool(s) used including version: Danish Q(SAR) database

Test material

Constituent 1
Chemical structure
Reference substance name:
Toluene-4-sulphonohydrazide
EC Number:
216-407-3
EC Name:
Toluene-4-sulphonohydrazide
Cas Number:
1576-35-8
Molecular formula:
C7H10N2O2S
IUPAC Name:
toluene-4-sulphonohydrazide
Test material form:
solid: particulate/powder

Administration / exposure

Route of administration:
oral: gavage
Vehicle:
not specified

Results and discussion

Preliminary study:
Rat Oral LD50 predicted to be 320 mg/kg bw/day. Reliability index of 0.59 (moderate prediction quality)
Effect levels
Key result
Sex:
not specified
Dose descriptor:
LD50
Effect level:
320 mg/kg bw

Applicant's summary and conclusion

Interpretation of results:
Category 3 based on GHS criteria
Remarks:
LD50 from 250 to 320 mg/kg bw
Executive summary:

No data is available for Toluene-4-sulphonohydrazide (TSH). However, QSAR prediction data shows that oral LD50 in rats and mice is 320 mg/kg bw/day and 1300 mg/kg bw/day, respectively. The predictions had a moderate prediction quality i.e., 0.59 and 0.52 for rats and mice, respectively.


In suppport, data from a recent study conducted according to OECD guideline 489 (in vivo mammalian alkaline comet assay) where Wister rats were treated by oral gavage with the Toluene-4-sulphonohydrazide, mortality was observed at a dose of 250 mg/kg 02.bw/day in males.Based on this TSH should be classified as Acute tox 3