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EC number: 216-407-3 | CAS number: 1576-35-8
Endpoint summary
Administrative data
Description of key information
No data available for p-TSH.
No reliable experimental data is available for toluene-4-sulphonohydrazide (TSH). However, the presumed breakdown product of Toluene-4-sulphonohydrazid, hydrazine (CAS No. 302-01-2), is officially recognized in the EU as a skin sensitizing compound and has a harmonized classification for Skin Sens. 1, H317. Based on QSAR predictions on TSH, TSH may liberate hydrazine and therefore it is justifiable that the substance is to be classified as Skin sens 1B H317 which is comparable to the harmonized classification for hydrazine.
No reliable QSAR-predictions on TSH could be made using VEGA, Danish DTU QSAR or the OECD Toolbox. Thus, a precautious approach would be to consider TSH as a skin sensitiser based on the properties of hydrazine. Therefore, it is concluded that TSH shall be classified as Skin sens 1 H317
Key value for chemical safety assessment
Skin sensitisation
Link to relevant study records
- Endpoint:
- skin sensitisation, other
- Remarks:
- QSAR prediction
- Type of information:
- (Q)SAR
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- results derived from a valid (Q)SAR model, but not (completely) falling into its applicability domain, with adequate and reliable documentation / justification
- Justification for type of information:
- No testing data on skin sensitisation is available for Toluene-4-sulphonohydrazid (TSH).
Predictions performed on dataset from different in silico prediction models (Danish QSAR database, QSAR Vega, ToxTree; OECD QSAR Toolbox) no valid conclusion can be derived for skin sentisation of TSH. - Principles of method if other than guideline:
- in silico prediction models
- Danish QSAR database
- QSAR Vega (v 1.2.0)
- ToxTree (v3.1.0-1851-1525442531402)
- OECD QSAR Toolbox - Key result
- Group:
- other:
- Run / experiment:
- other: QSAR prediction
- Parameter:
- other: QSAR prediction
- Cell viability:
- QSAR model
- Vehicle controls validity:
- not examined
- Negative controls validity:
- not examined
- Positive controls validity:
- not examined
- Remarks on result:
- other: No valid prediction could be derived from QSAR models
- Key result
- Reading:
- other: QSAR prediction
- Group:
- other: QSAR prediction
- Remarks on result:
- other: No valid prediction could be derived from QSAR models
- Key result
- Parameter:
- other: QSAR prediction
- Remarks on result:
- other: No valid prediction could be derived from QSAR models
- Interpretation of results:
- Category 1 (skin sensitising) based on GHS criteria
- Conclusions:
- The presumed breakdown product of Toluene-4-sulphonohydrazid (TSH), hydrazine (CAS No. 302-01-2), is officially recognized in the EU as a skin sensitizing compound and has a harmonized classification for Skin Sens. 1 (H317). When applied to skin, TSH is expected to slowly hydrolyse to hydrazine due to the moisture in the skin. A small amount of hydrazine may be generated and could induce skin sensitization.
- Executive summary:
No testing data on skin sensitisation is available for Toluene-4-sulphonohydrazid (TSH).
Form QSAR prediction on skin sensitisation using the Danish QSAR database (see attached prediction report), no valid prediction could be derived using a battery approach (3 seperate predictions from CASE Ultra, Leadscope and SciQSAR). The predictions for skin sensitisation and irritation in animal models (Guinea pig and rabbit) was outside applicability domain. Further, in the same prediction report from the Danish QSAR database, no alert for protein binding and potency estimation was found using different models (OASIS, OECD QSAR Toolbox, DRPA).
Prediction on skin sensitisation of TSH using the QSAR Vega tool (CAESAR model) revealed a positive prediction but with low reliability score (see attached prediction report).
Also, using the Toxtree programme, no alrets was identified for skin sensitisastion.
Based on the overall dataset from different in silico prediction models (Danish QSAR database, QSAR Vega, ToxTree; OECD QSAR Toolbox) no valid conclusion can be derived for skin sentisation of TSH.
The presumed breakdown product of Toluene-4-sulphonohydrazid (TSH), hydrazine (CAS No. 302-01-2), is officially recognized in the EU as a skin sensitizing compound and has a harmonized classification for Skin Sens. 1 (H317). When applied to skin, TSH is expected to slowly hydrolyse to hydrazine due to the moisture in the skin. A small amount of hydrazine may be generated and could induce skin sensitisatin.
Thus, a precautinary approach would be to consider TSH as a skin sensitiser and classify accordingly (Skin Sens. 1 (H317).
Reference
No testing data on skin sensitisation available for TSH.
Using different QSAR models, no valid prediction could be made. Only one model predicted TSH to have skin sensitising properties, but this prediction was with low reliability.
The presumed breakdown product of Toluene-4-sulphonohydrazid (TSH), hydrazine (CAS No. 302-01-2), is officially recognized in the EU as a skin sensitizing compound and has a harmonized classification for Skin Sens. 1 (H317). When applied to skin, TSH is expected to slowly hydrolyse to hydrazine due to the moisture in the skin. A small amount of hydrazine may be generated and could induce skin sensitisation.
Therefore, as a precautious approach TSH is classified accordingly as a skin sensitiser (Skin Sens. 1 (H317).
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (sensitising)
Respiratory sensitisation
Endpoint conclusion
- Endpoint conclusion:
- no study available
Justification for classification or non-classification
No reliable experimental data is available for toluene-4-sulphonohydrazide (TSH). However, information of presumed breakdown productions for Toluene-4-sulphonohydrazide is available and has been used for the conclusion on skin sensitisation for TSH.
The presumed breakdown product of Toluene-4-sulphonohydrazid (TSH), hydrazine (CAS No. 302-01-2), is officially recognized in the EU as a skin sensitizing compound and has a harmonized classification for Skin Sens. 1, H317. Based on QSAR predictions on TSH, p-TSH may liberate hydrazine and therefore it is justifiable that the substance is to be classified as Skin sens 1B H317 which is comparable to the harmonized classification for hydrazine.
Thus, a precautious approach would be to consider TSH as a skin sensitiser based on data from presumed break down products and classify accordingly as Skin Sens. 1 (H317).
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