Registration Dossier
Registration Dossier
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EC number: 216-407-3 | CAS number: 1576-35-8
Endpoint summary
Administrative data
Description of key information
Additional information
Three acute toxicity studies on algae, invertebrates and fish are available for the substance:
Short-term toxicity to fish, conducted according to OECD Guideline no. 203 and GLP, with test substance toluene-4-sulphonohydrazide and test organism ricefish (Oryzias latipes), showed a 96hr-LC50 (95% confidence limits) value expressed in terms of the time-weighted mean concentration of 3.21mg/L (2.29-4.50mg/L).
To assess the acute toxicity of toluene-4-sulphonohydrazide a study according to OECD Guideline No. 202 was conducted. The 48hr-EC50 value (95% confidence limits) expressed in terms of the time-weighted mean concentration of toluene-4-sulphonohydrazide to Daphnia magna were determined to 2.71 mg/L (2.41-3.06 mg/L) and NOEC was 1.12 mg/L. mg/L) and NOEC was 1.12 mg/L.
The growth inhibition effects of Toluene-4-sulphonohydrazide was assessed according to OECD Guideline No. 201. The test resulted in 72-hr EC50 values (95% confidence limits) expressed in terms of the geometric mean measured concentration of Toluene-4-sulphonohydrazide to Pseudokirchneriella subcapitata were 10.2 mg/L (9.67-10.5 mg/L) for average growth rate and 3.07 mg/L (1.94-3.74 mg/L) for yield. The No Observed Effect Concentration (NOEC) and Lowest Observed Effect Concentration(LOEC) values expressed in terms of the mean measured concentration were 0.275 mg/L and 0.912 mg/L for average growth rate and yield.
In addition, a toxicity study on microorganism is available.
The test item was tested according to OECD Guideline no 209: Activated Sludge, Respiration Inhibition Test. The study was conducted according to GLP. Resulting EC50 = 911 mg/L (30 min), EC20 = 244 mg/L (30 min), EC50 = 641 mg/L (180 min) and EC20=186 mg/L (180 min).
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