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Skin irritation / corrosion

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Administrative data

Endpoint:
skin irritation: in vivo
Type of information:
(Q)SAR
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Justification for type of information:
No testing data on skin irriation is available for Toluene-4-sulphonohydrazide (TSH).
Use of Danish QSAR database and ToxTree; and classification of two pressumed breakdown products

Data source

Reference
Reference Type:
other: Q(SAR) prediction report
Title:
(Q)SAR predicted profile for toluene-4-sulphonohydrazide
Year:
2022
Bibliographic source:
Danish Q(SAR) database
Report date:
2022

Materials and methods

Principles of method if other than guideline:
in silico prediction models
- Danish QSAR database
- ToxTree (v3.1.0-1851-1525442531402)

Test material

Constituent 1
Chemical structure
Reference substance name:
Toluene-4-sulphonohydrazide
EC Number:
216-407-3
EC Name:
Toluene-4-sulphonohydrazide
Cas Number:
1576-35-8
Molecular formula:
C7H10N2O2S
IUPAC Name:
toluene-4-sulphonohydrazide
Test material form:
solid: particulate/powder

Results and discussion

In vivo

Results
Irritation parameter:
other: QSAR prediciton
Remarks on result:
other: QSAR predicitons considered equivocal

Applicant's summary and conclusion

Interpretation of results:
Category 2 (irritant) based on GHS criteria
Conclusions:
it is considered appropriate to classify the substance as skin irrit.2
Executive summary:

No testing data on skin irriation is available for Toluene-4-sulphonohydrazide (TSH).


From QSAR predicitons on skin irriation using the Danish QSAR database (see attached prediction report), only one out of three seperate predictions from CASE Ultra, Leadscope and SciQSAR was considered valid (i.e., SciQSAR: Negative_ in scope). The leadscope had a positive prediction for skin irritation (out of scope) and the CASEultra had an inconclusive prediction for skin irriation. The overal prediciton results for skin irriation are equivocal. Using the Toxtree programme, no alerts were identified for skin irriation.


 


Based on the overall dataset from different in silico prediction models (Danish QSAR database and ToxTree) no valid conclusion can be derived for skin irritation of TSH.


 


However, data from the presumed breakdown products of TSH can be used for the evaluation of the skin irritative potential of TSH. When applied to skin, TSH is expected to slowly hydrolyse due to the moisture in the skin with the presumed products being toluene-4-sulphonic acid (CAS No. 104-15-4) and hydrazine (CAS No. 302-01-2). This hydrolysis is though evaluated to be slow indicating that the concentration of the breakdown products also is low. 


 


Toluene-4-sulphonic acid (CAS No. 104-15-4) has a harmonized classification for Skin Irrit. 2, H315. Furthermore, toluene-4-sulphonic acid is considered as skin corrosive since > 500 notifiers in the ECHA CLP database have classified the substance as Skin Corr. 1C.


 


Hydrazine (CAS No. 302-01-2) may be generated and could induce skin damage. Hydrazine, has a harmonized classification for Skin Corr. 1B.


 


Based on the skin irritation and corrosiveness of the two pressumed breakdown products it is considered appropriate as a precautionary approach to classify TSH as skin irrit.2 here without further testing.