Phosphonium, trihexyltetradecyl-, chloride

Toxicity to aquatic algae and cyanobacteria

Link to relevant study record(s)

Reference

Endpoint:

toxicity to aquatic algae and cyanobacteria

Type of information:

experimental study

Adequacy of study:

supporting study

Study period:

2006

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

other: Data is from peer reviewed journal. Study conducted according a standardised method.

Reason / purpose for cross-reference:

reference to same study

Reason / purpose for cross-reference:

reference to same study

Qualifier:

according to guideline

Guideline:

OECD Guideline 201 (Alga, Growth Inhibition Test)

Version / remarks:

Adopted 7 June 1984

GLP compliance:

not specified

Specific details on test material used for the study:

Composition of test material, percentage of components: Trihexyl(tetradecyl)phosphonium chloride (258864-54-9), >= 95%

Analytical monitoring:

yes

Details on sampling:

Chemical analysis of the test solution was carried out at the beginning and end of the test to ensure that organism exposure was consistent with that expected from nominal concentrations used.

Vehicle:

no

Test organisms (species):

Raphidocelis subcapitata (previous names: Pseudokirchneriella subcapitata, Selenastrum capricornutum)

Test type:

not specified

Water media type:

freshwater

Limit test:

no

Total exposure duration:

72 h

Hardness:

Not specified

Test temperature:

Not specified

pH:

Not specified

Dissolved oxygen:

Not specified

Salinity:

Not specified

Conductivity:

Not specified

Nominal and measured concentrations:

Not specified

Details on test conditions:

Algal cultures in exponential growth phase were exposed to various concentration of the test material for 72h at which point the growth of the culture was examined by electronic particle counting techniques.

Reference substance (positive control):

not specified

Duration:

48 h

Dose descriptor:

EC50

Effect conc.:

0.042 mg/L

Nominal / measured:

nominal

Conc. based on:

test mat.

Basis for effect:

growth rate

Remarks on result:

other: 95% CI (mg/L): 0.037 - 0.048

Details on results:

Although the test duration was 72h, only the results at 48h are available in the publication.
Note that for this test material, the end-point chemical analysis showed that the final concentration in the medium was less than 10% of the initial nominal concentration.

Results with reference substance (positive control):

Some common solvents were tested concurrently and the results are similar to those available previously.

Validity criteria fulfilled:

not specified

Conclusions:

The acute toxicity of Trihexyltetradecylphosphonium chloride to Pseudokirchneriella subcapitata was investigated in accordance with OECD guideline 201. The 48-h EC50 was 0.042 mg/L.

Executive summary:

In this study, the acute toxicity of the test substance (Trihexyltetradecylphosphonium chloride) to Pseudokirchneriella subcapitata was determined in a 48 hour test according to the OECD Guideline No. 201 (1984). Under the conditions of this study, a 48h EC50 of 0.042 mg/L was obtained.

Description of key information

In this study, the acute toxicity of the test substance (Trihexyltetradecylphosphonium chloride) to Pseudokirchneriella subcapitata was determined in a 48 hour test according to the OECD Guideline No. 201 (1984). Under the conditions of this study, a 48h EC50 of 0.042 mg/L was obtained.

Key value for chemical safety assessment

EC50 for freshwater algae:

0.042 mg/L