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EC number: 684-206-1 | CAS number: 258864-54-9
A GLP-compliant acute toxicity study according to OECD Guideline 402 was conducted. Three male and 3 female Sprague Dawley rats were exposed to a single dose of Trihexyltetradecylphosphonium chloride at 2000 mg/kg bw. The rats were observed for 14 days.
Abnormal physical signs including brown staining of the nose/mouth area, partially chewed food in pan liner, unkempt appearance, localized hair loss (inside of hind legs and on abdomen), prolapsed penis, chromorhinorrhea, and chromodacryorrhea were observed.
At 24 hours post-dosing, erythema was absent to severe and edema was slight to moderate; pale and dark areas were observed. By Day 14, erythema was absent to severe and edema was absent; moderate to severe eschar formation, necrotic and flaking skin, shiny areas and poor hair regrowth were observed.
In conclusion, the dermal LD50 value of Trihexyltetradecylphosphonium chloride in Sprague Dawley rats was established to be greater than 2000 mg/kg body weight.
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