Registration Dossier
Registration Dossier
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EC number: 266-046-0 | CAS number: 65997-17-3 This category encompasses the various chemical substances manufactured in the production of inorganic glasses. For purposes of this category, 'glass' is defined as an amorfous, inorganic, transparent, translucent or opaque material traditionally formed by fusion of sources of silica with a flux, such as an alkali-metal carbonate, boron oxide, etc. and a stabilizer, into a mass which is cooled to a rigid condition without crystallization in the case of transparent or liquid-phase separated glass or with controlled crystallization in the case of glass-ceramics. The category consists of the various chemical substances, other than by-products or impurities, which are formed during the production of various glasses and concurrently incorporated into a glass mixture. All glasses contain one or more of these substances, but few, if any, contain all of them. The elements listed below are principally present as components of oxide systems but some may also be present as halides or chalcogenides, in multiple oxidation states, or in more complex compounds. Trace amounts of other oxides or chemical compounds may be present. Oxides of the first seven elements listed* comprise more than 95 percent, by weight, of the glass produced. @Aluminium*@Lead@Boron*@Lithium@Calcium*@Manganese@Magnesium*@Molybdenum@Potassium*@Neodymium@Silicon*@Nickel@Sodium*@Niobium@Antimony@Nitrogen@Arsenic@Phosphorus@Barium@Praseodymium@Bismuth@Rubidium@Cadmium@Selenium@Carbon@Silver@Cerium@Strontium@Cesium@Sulfur@Chromium@Tellurium@Cobalt@Tin@Copper@Titanium@Germanium@Tungsten@Gold@Uranium@Holmium@Vanadium@Iron@Zinc@Lanthanum@Zirconium
Endpoint summary
Administrative data
Description of key information
Key value for chemical safety assessment
Skin sensitisation
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not sensitising)
- Additional information:
Testing of skin sensitization is waived based on the fact that E-glass microfibre is inorganic and chemically inert. Its physicochemical properties suggest a low potential to penetrate the skin. Skin penetration is prerequisite for the LLNA test. It is assessed that E-glass microfibre will not be able to induce skin sensitisation in humans.
Migrated from Short description of key information:
E-glass microfibre is chemically inert and assessed not to be a skin sensitiser in humans. E-glass microfibre shall not be classified as a skin sensitiser according to the criteria in Council Directive 67/548/EEC and Regulation (EC) 1272/2008.
Respiratory sensitisation
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not sensitising)
- Additional information:
Workers have been exposed to man-made vitreous fibres (MMVF) by inhalation for many years without any indication for induction of respiratory sensitisation. It is thus assessed that E-glass microfibre does not induce respiratory sensitisation in humans.
Migrated from Short description of key information:
E-glass microfibre is chemically inert and assessed not to be a respiratory sensitiser in humans. E-glass microfibre shall not be classified as a respiratory sensitiser according to the criteria in Council Directive 67/548/EEC and Regulation (EC) 1272/2008.
Justification for classification or non-classification
E-glass microfibre is inorganic. Its physicochemical properties suggest a low potential to cross biological membranes, making it unlikely that E-glass microfibre should possess sensitising properties. Furthermore, many years of worker exposure to mineral wool (MMVF) by dermal contact and by inhalation has not in known cases of skin or respiratory sensitisation. It is assessed that E-glass microfibre is not a skin sensitiser or a respiratory sensitiser. E-glass microfibre shall not be classified as a skin or respiratory sensitiser according to the criteria in Council Directive 67/548/EEC and Regulation (EC) 1272/2008.
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