Registration Dossier
Registration Dossier
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EC number: 266-046-0 | CAS number: 65997-17-3 This category encompasses the various chemical substances manufactured in the production of inorganic glasses. For purposes of this category, 'glass' is defined as an amorfous, inorganic, transparent, translucent or opaque material traditionally formed by fusion of sources of silica with a flux, such as an alkali-metal carbonate, boron oxide, etc. and a stabilizer, into a mass which is cooled to a rigid condition without crystallization in the case of transparent or liquid-phase separated glass or with controlled crystallization in the case of glass-ceramics. The category consists of the various chemical substances, other than by-products or impurities, which are formed during the production of various glasses and concurrently incorporated into a glass mixture. All glasses contain one or more of these substances, but few, if any, contain all of them. The elements listed below are principally present as components of oxide systems but some may also be present as halides or chalcogenides, in multiple oxidation states, or in more complex compounds. Trace amounts of other oxides or chemical compounds may be present. Oxides of the first seven elements listed* comprise more than 95 percent, by weight, of the glass produced. @Aluminium*@Lead@Boron*@Lithium@Calcium*@Manganese@Magnesium*@Molybdenum@Potassium*@Neodymium@Silicon*@Nickel@Sodium*@Niobium@Antimony@Nitrogen@Arsenic@Phosphorus@Barium@Praseodymium@Bismuth@Rubidium@Cadmium@Selenium@Carbon@Silver@Cerium@Strontium@Cesium@Sulfur@Chromium@Tellurium@Cobalt@Tin@Copper@Titanium@Germanium@Tungsten@Gold@Uranium@Holmium@Vanadium@Iron@Zinc@Lanthanum@Zirconium
Endpoint summary
Administrative data
Key value for chemical safety assessment
Effects on fertility
Additional information
E-glass microfibre is inorganic and have low biological activity. E-glass microfibre does not translocate after intake (ingestion or inhalation). E-glass microfibre is not biosoluble, does not have leaching potential and is not dissolved in the lung fluid after inhalation. Due to these characteristics it is evaluated that exposure of males and females in a pre-mating period will not affect the fertility. It is evaluated that the continued exposure of the females after fertilisation (the dams) will not result in exposure of foetuses and, hence, no effect in the foetuses is expected.
Short description of key information:
The study of this end-point is waived. E-glass microfibre is inorganic and have low biological activity. E-glass microfibre does not translocate after intake (ingestion or inhalation except into the pleura). E-glass microfibre is not biosoluble, does not have leaching potential and is not dissolved by the lung fluid after inhalation. Due to these characteristics it is evaluated that exposure of males and females in a pre-mating period will not affect the fertility. Further, it is evaluated that the continued exposure of the females after fertilisation (the dams) will not result in exposure of foetuses and, hence, no effect to the foetuses is expected.
Effects on developmental toxicity
Description of key information
The study of this end-point is waived. E-glass microfibre is inorganic and have low biological activity. E-glass microfibre does not translocate after intake (ingestion or inhalation). E-glass microfibre is not biosoluble, does not have leaching potential and is not dissolved by the lung fluid after inhalation. Due to these characteristics it is assessed that exposure of males and females in a pre-mating period will not affect the fertility. Further, it is evaluated that the continued exposure of the females after fertilisation (the dams) will not result in exposure of foetuses and, hence, no effect to the foetuses is expected.
Additional information
E-glass microfibre is inorganic and have low biological activity. E-glass microfibre does not translocate after intake (ingestion or inhalation). E-glass microfibre is not biosoluble, does not have leaching potential and is not dissolved by the lung fluid after inhalation. Due to these characteristics it is assessed that exposure of males and females in a pre-mating period will not affect the fertility. Further, it is evaluated that the continued exposure of the females after fertilisation (the dams) will not result in exposure of foetuses and, hence, no effect to the foetuses is expected.
Justification for classification or non-classification
E-glass microfibre is inorganic and have low biological activity. E-glass microfibre does not translocate after intake (ingestion or inhalation). E-glass microfibre is not biosoluble, does not have leaching potential and is not dissolved by the lung fluid after inhalation. Due to these characteristics it is assessed that exposure of males and females in a pre-mating period will not affect the fertility. Further, it is assessed that the continued exposure of the females after fertilisation (the dams) will not result in exposure of foetuses and, hence, no effect in the foetuses is expected. Therefore, E-glass microfibre shall not be classified as toxic to fertility or development, i.e. not toxic to reproduction.
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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