1,2-dichloro-3-nitrobenzene

Toxicity to terrestrial arthropods

Link to relevant study record(s)

Reference

Endpoint:

toxicity to terrestrial arthropods: short-term

Type of information:

experimental study

Adequacy of study:

other information

Reliability:

4 (not assignable)

Rationale for reliability incl. deficiencies:

secondary literature

Principles of method if other than guideline:

acute toxicity of 2,3-dichloronitrobenzene to Drosophila melanogaster was tested by injection of a solution the test substance into the fly and by feeding of a solution of the test substance

GLP compliance:

not specified

Analytical monitoring:

not specified

Vehicle:

yes

Details on preparation and application of test substrate:

- a stock solution was prepared in 0.6-3% of ethanol in water
- in case of the injection test the stock solution was diluted with a 0.7% solution of sodium chloride in water
- in case of the feeding test the stock solution was diluted with a 5% solution of saccharose in water

Test organisms (species):

Drosophila melanogaster

Animal group:

Diptera (fruit fly (small))

Details on test organisms:

- only male flies were tested

Nominal and measured concentrations:

- in both experiments (injection + feeding) a nominal concentration of 20 mg/l was tested

Injection test (24 hours)

LC11 = 20 mg/l

Sterility rate: 1%

 

Feeding test (72 hours)

LC30 = 20 mg/l

Sterility rate: 2%

Conclusions:

acute toxicity of 2,3-dichloronitrobenzene to Drosophila melanogaster was tested by injection of a solution the test substance into the fly and by feeding of a solution of the test substance. Only male flies were tested. A LC 50 = 20 mg/L was derived (sterility).

Executive summary:

acute toxicity of 2,3-dichloronitrobenzene to Drosophila melanogaster was tested by injection of a solution the test substance into the fly and by feeding of a solution of the test substance. Only male flies were tested. A LC 50 =  20 mg/L was derived (sterility).

Description of key information

For transported isolated intermediates according to Reach, Annex XVIII, this endpoint is not a data requirement. However, data is available for this endpoint and is thus reported under the guidance of "all available data".

Acute toxicity of 2,3-dichloronitrobenzene to Drosophila melanogaster was tested by injection of a solution the test substance into the fly and by feeding of a solution of the test substance. Only male flies were tested. A LC 50 =  20 mg/L was derived (sterility).