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EC number: 266-380-7
CAS number: 66492-51-1
In an acute dermal toxicity study (Limit Test), young adult Wistar rats
(5 males and 5 females) were dermally exposed to a single dose of 2000
mg/kg bw of undiluted test item to the clipped skin (dorsal and
dorso-lateral parts of the trunk) and covered by semi-occlusive dressing
for 24 hours. The application area comprised at least 10% of the total
body surface area. The animals were observed for 14 days. The following
test item-related local effects were recorded during the course of the
· No mortality occurred
· No signs of systemic toxicity were observed in the animals
· Slight to moderate erythema (grade 1 to 3)
· Slight to well-defined edema (grade 1 to 2)
· Severe scaling
· Skin findings beyond the application area
· Significant scratching behavior
· The mean body weight of the animals increased within the normal range
throughout the study period
· No macroscopic pathologic abnormalities were noted in the animals
examined at the end of the study.
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