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EC number: 266-380-7
CAS number: 66492-51-1
There are no studies available for the determination of toxicokinetics
or dermal absorption.
(5-ethyl-1,3-dioxan-5-yl)methyl acrylate is a liquid with a molecular
weight of 200 g/mol and a low vapour pressure of 0.6Pa at 20 °C. In
agreement with its logPow of 1.9, up to 9.3g can be dissolved in one
liter of water. Due to its low vapour pressure, exposure to vapor is
unlikely. Acute dermal toxicity tests as well as oral acute and repeated
dose studies showed no signs of systemic toxicity, but irritation at the
site of entry. In the acute toxicity study one female died due to
extensive bleeding in the glandular stomach after a single dose of
2000mg/kg. The remaining animals showed an impaired general state mostly
up to 5 hours after dosing, probably also due to the irritant properties
of the test substance. In a test study to select the doses for the OECD
422 study, 1 of 3 animals died on day 13 after daily exposure to
1000mg/kg. All animals of this group had erosions / ulcers in the
glandular and/or forestomach. Even after 14 day exposure to 500mg/kg,
ulcers observed in one animal were considered severe enough to cause
death after prolonged exposure. In the main study performed with
250mg/kg at the top dose, hyperkeratosis was observed in the forestomach
of 7 out of 10 males, while no signs of systemic toxicity were found.
Based on the moderate logPow (between -1 and 4) of the test substance
and its low molecular weight, absorption through the GI-tract seems
likely, but the substance is not expected to bioaccumulate. It is
assumed, that the molecule is metabolized via hydrolyzation of the ester
bond into acrylic acid and 5 -ethyl-1,3 -dioxane-5 -methanol. Since
severe irritation occured at doses at and above 500mg/kg in the stomach
after oral exposure (the substance itself has a pH value of 7 and is not
irritating on mucosal surfaces), generation of acrylic acid and 5
-Ethyl-1,3-dioxane-5-methanol might already take place in the stomach.
Acrylic acid is rapidly exhaled as CO2, while
5-Ethyl-1,3-dioxane-5-methanol is even more hydrophilic than the parent
compound (logPow = 0.08) and probably excreted via urine.
No mutagenicity or chromosomal aberration was observed for the parent
compound (Ames, HPRT, MNT), or the proposed metabolic products, so no
reactivity with macromolecules is expected prior to excretion.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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