Registration Dossier
Registration Dossier
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EC number: 807-715-4 | CAS number: 1354569-12-2
Bioaccumulation: aquatic / sediment
Administrative data
Link to relevant study record(s)
Description of key information
A QSAR model (BCFBAF; Klimisch 2) predicts a bioconcentration factor of 1655 L/kg wet-wt, and whole-body biotransformation rate estimate (HLN) 0.43 d for fish. The third model was not reliable (Klimisch 3).
Key value for chemical safety assessment
- BCF (aquatic species):
- 1 655 L/kg ww
Additional information
BCF was estimated by EPISuite v 4.11 (BCFBAF v. 3.01).
The following estimates can be considered as reliable with restrictions (Klimisch 2):
The BCF regression model estimate for the bioconcentration factor was 1655 L/kg wet-wt based on log P.
The whole-body primary biotransformation half-life rate estimate (HLN) for fish was 0.43 d ("normalized” for a 10 g fish at 15ºC).
The results are used as weight of evidence in PBT assessment.
The Arnot-Gobas model was rated as not reliable (Klimisch 3) due to lack of method and validation details.
The BCF estimate for the upper trophic tier was 18.78 L/kg wet-wt (including biotransformation) and 5480 L/kg wet-wt (assuming a biotransformation rate of zero).
Conclusion: A QSAR model (BCFBAF) estimates a bioconcentration factor of 1655 L/kg wet-wt, and whole-body biotransformation rate estimate (HLN) 0.43 d for fish. Biotransfromation is expected to occur instead of bioaccumulation.
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