Registration Dossier
Registration Dossier
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EC number: 807-715-4 | CAS number: 1354569-12-2
Endpoint summary
Administrative data
Description of key information
Additional information
Bis (2 -ethylhexyl)citraconate is not hydrolysable (modelled half-life at pH 7 was 49 years; HYDROWIN 2.00). The result was used as weight of evidence for classification and labelling and PBT assessment.
The test substance bis(2 -ethylhexyl)citraconate is assessed as not readily biodegradable for classification and labelling based on a screening non-GLP OECD 301 D Test. Therein the substance was observed not to inhibit growth of micro-organisms at 2.3 mg/L nominal concentration. The available QSAR models BIOWIN 4.10 and STPWIN however provide some weight of evidence of ultimate biodegradability, for which no valid experimental test result is available. The BIOWIN model is however assessed to overpredict biodegradability of structurally analogous compounds. This conclusion is used as weight of evidence for PBT assessment.
The estimated bioconcentration factor was 1655 L/kg wet-wt by a BCF regression model based on log P (BCFBAF 3.01). However, as the whole-body primary biotransformation half-life rate estimate for fish was 0.43 d ("normalized” for a 10 g fish at 15ºC by the Arnot 2008 model of BCFBAF 3.01), biotransformation is expeted to prevent bioaccumulation in the food chain. A more detailed three trophic tier modelling (Arnot-Gobas 2003 of BCFBAF 3.01) result of support the conclusion. The results are used as weight of evidence in PBT assessment.
Bis(2 -ethylhexyl)citraconate has high adsorption tendency to organic carbon (estimated log Koc 4.6 by KOCWIN 2.00), and very low volatity from aqueous environment to the atmosphere (estimated Henry's coefficient 0.000013 atm m3/mol at 25oC and 101.3 kPa by HENRYWIN 3.2).
There is weight of evidence from eight QSAR models (EPA PBT Profiler 2.0 and MacKay Level III Fugacity Model of EPISuite
4.11) that when released to the environment, the test substance is mainly distributing to soil and sediment compartments, where it is biodedegraded in days or weeks. In addition, the modelled bioconcentration factor was 630 by the EPA PBT profiler 2.0.Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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