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EC number: 603-837-5
CAS number: 134605-64-4
Freshwater: 48 hour LC50 > 8.6 mg a.i./L, Daphnia magna, EPA OPP 72-2, EPA 540/9-85-005, ASTM E729-88a, Drottar & Swigert 1996cMarinewater: LC50 0.14 mg a.i./L, Mysidopsis bahia, EPA OPP 72-3, EPA 540/9-85-010, ASTM E729-88a, Roberts & Swigert 1996b
One study has been provided to address short term toxicity to
aquatic invertebrates in freshwater and two studies to address acute
toxicity in marine water.
The short-term toxicity to freshwater aquatic invertebrates was
determined in an acute toxicity study performed using Daphnia magna.The
test was conducted in line with GLP and in accordance with the
standardised guidelines EPA OPP 72-2, EPA 540/9-85-005 and ASTM
E729-88a. Daphnids were exposed to the test material at measured
concentrations of 1.6, 2.5, 4.4, 6.2 and 8.6 mg a.i./L under
flow-through freshwater conditions for 48 hours. Under the conditions of
the test, no mortality, immobility or clinical signs of toxicity were
observed in daphnids exposed to the test material. Negative and solvent
controls displayed a mean percentage mortality rate of 5%. Based on the
observations made, the EC50was determined to be > 8.6 mg a.i./L, the
highest concentration tested. The NOEC was determined to be 8.6 mg
The short-term toxicity to aquatic invertebrates was determined in an
acute saltwater toxicity study performed on Mysidopsis bahia, in
line with GLP and in accordance with the standardised guidelines EPA OPP
72-3, EPA 540/9-85-010 and ASTM E729-88a (Roberts and Swigert, 1996b).
Organisms were exposed to the test material at measured concentrations
of 0.043, 0.068, 0.12, 0.19 and 0.30 mg a.i./L under flow-through
saltwater conditions for 96 hours. Under the conditions of the test
mortality was observed at concentrations ≥ 0.12 mg a.i./L. By
termination mortality reached 30%, 85% and 100% in the 0.12, 0.19 and
0.30 mg a.i./L treatment groups, respectively. Clinical and behaviour
observations were noted at concentrations ≥ 0.068 mg a.i./L and included
erratic swimming behaviour and lethargy. Based on these observation the
LC50was determined to be 0.14 mg a.i./L at 96 hours, with 95% confidence
limits of 0.12 and 0.16 mg a.i./L. The NOEC was determined to be 0.043
mg a.i./L. This study was chosen as the key study for marine water
species on the basis that the endpoint values are more worst-case than
the supporting study detailed below.
The short-term toxicity to aquatic invertebrates was determined in
an acute saltwater toxicity study performed on Crassostrea virginica. The
study was conducted in line with GLP and the standardised guidelines EPA
OPP 72-3 and EPA 540/9-85-011 (Roberts and Swigert, 1996c). Oysters were
exposed to the test material at measured concentrations of 0.82, 1.3,
1.9, 3.1 and 4.4 mg a.i./L under flow-through saltwater conditions for
96 hours. Under the conditions of the test shell growth inhibition was
shown to be statistically significant (p≤0.05) in the 3.1 and 4.4 mg
a.i./L exposure groups, with calculated inhibition of 70% and 88%
respectively. Average shell growth at these concentrations was 0.70 and
0.27 mm in comparison to the pooled controls which was 2.33
mm. The 96 hour EC50 was determined to be 2.7 mg a.i./L, with 95%
confidence limits of 2.5 and 2.9 mg a.i./L. The NOEC was determined to
be 1.9 mg a.i/L.
All studies were performed to a high standard, in line with GLP
and in accordance with standardised guidelines. They have thus been
assigned a reliability score of 1 in line with the principles for
assessing data quality set out in Klimisch (1997). The available data
are deemed to be relevant, reliable and adequate for the purposes of
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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