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EC number: 603-837-5
CAS number: 134605-64-4
Freshwater: NOEC 11 µg a.i./L, LOEC 22 µg a.i./L, early life-stage toxicity, Oncorhynchus mykiss, EPA OPP 72-4, EPA 540/9-86-138, ASTM E1241-88a, Palmer & Krueger 1998
The long-term toxicity to fish was determined in an early-life stage
toxicity study performed using Oncorhynchus mykiss.The test was
conducted in line with GLP and in accordance with the standardised
guidelines EPA OPP 72-4, EPA 540/9-86-138 and ASTM E1241-88a. Embryos
were exposed to the test material at measured concentrations of 5.3, 11,
22, 43 and 90 µg a.i./L under flow-through freshwater conditions for 28
days. Embryos, larval and fish were observed for fertilisation success,
hatching success, time to hatch, time to swim-up of the larvae and
post-hatch survival, clinical signs of toxicity and growth.
Under the conditions of the test no apparent treatment related effects
were observed at concentrations ≤ 11 µg a.i./L in comparison to the
pooled controls. This conclusion was based on the following parameters;
time to hatch, hatching success, time to swim-up, larval survival, fry
survival and growth. In comparison to the control significant (p ≤ 0.05)
reductions in larval survival from hatch until thinning, time to swim-up
and growth at termination were observed in the 22 µg a.i./L exposure
group. At the highest concentrations tested, 43 and 90 µg a.i./L, a
significant (p ≤ 0.05) reduction in comparison to the controls was
observed for hatching success, time to swim-up, larval and fry survival
Therefore the most sensitive parameters were identified as larval
survival, time to reach swim-up and growth. Consequently the LOEC was
determined to be 22 µg a.i./L and the NOEC 11 µg a.i./L based on the
most sensitive data. Based on the LOEC and NOEC the MATC was calculated
to be 16 µg a.i./L. The study is considered to be reliable, relevant and
adequate for risk assessment purposes.
The study was performed to a high standard, in line with GLP and
standardised guidelines. Accordingly the study has been assigned a
reliability score of 1 in line with the principles for assessing data
quality set out in Klimisch (1997). The available data are deemed to be
relevant, reliable and adequate for the purposes of risk assessment.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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